Hospital Universitario Ramón y Cajal

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...

Drug-related problems and pharmacist interventions within a pharmaceutical care programme in allogeneic haematopoietic stem cell transplantation

Background Patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT) are exposed to highly complex pharmacotherapy, substantially increasing the risk of drug-related problems (DRPs). Objective To describe the frequency, causes and status of DRPs, as well...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Real-world safety and clinical outcomes of cluster subcutaneous immunotherapy with olive pollen extracts, with or without grass pollen, in patients with allergic rhinoconjunctivitis and/or asthma

Abstract Background Allergen immunotherapy (AIT) is the only treatment capable of modifying the natural course of IgE-mediated allergic diseases induced by aeroallergens. Cluster schedules for subcutaneous AIT (SCIT) with hypoallergenic depot extracts enable faster dose escalatio...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

A Structured Framework for Translation of the ACNS Standardized Critical Care EEG Terminology Into Spanish

Purpose: The American Clinical Neurophysiology Society (ACNS) Critical Care EEG Terminology provides standardized language for describing electroencephalographic (EEG) patterns in critically ill patients but has not been formally translated into Spanish. We aimed to develop a con...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Theranostics in the management of prostate cancer: from concept to clinical practice

INTRODUCTION: Radiotheranostics, integrating diagnostic imaging with targeted radiotherapy using molecularly matched radioactive agents, has emerged as a transformative approach in the management of prostate cancer. Prostate-specific membrane antigen (PSMA) is the dominant clinic...

Ultrasensitive serum levels of interleukin 13 in systemic lupus erythematosus patients: a cross-sectional study

Systemic lupus erythematosus (SLE) is characterized by elevated levels of various cytokines. Interleukin (IL)-13 is a pleiotropic type 2 cytokine that plays a central role in allergic inflammation and tissue fibrosis. Until recently, serum measurement of IL-13 was not feasible be...

Interictal electric source imaging with open‐source software and routine low‐density electroencephalography: A systematic comparison of four inverse methods in drug‐resistant epilepsy

Abstract Objective This study was undertaken to assess the diagnostic accuracy of interictal electrical source imaging (ESI) performed using open‐source software and routine low‐density electroencephalography (LD‐EEG), comparing four inverse methods at two spike time points. Meth...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Mammalian Predators and Red-Legged Partridge (Alectoris rufa) Releases: A Case Study

We performed a before–after control–impact (BACI) experiment to assess the impact of red-legged partridge releases on mammalian predators, a common game management measure. During three consecutive years (2014–2016), 100 farm-reared red-legged partridges were kept every year for...

Psychological interventions for individuals affected by Huntington’s disease: effects on depression, anxiety, and emotional well-being

Abstract Introduction The literature provides limited evidence on the effectiveness of psychological interventions for individuals living with Huntington’s Disease (HD). This study aims to examine the role of psychological support in improving the well-being of individuals and fa...

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Spironolactone versus Bicalutamide for Female Pattern Hair Loss: A 24-Month Unicenter Retrospective Comparative Study of Effectiveness and Safety

INTRODUCTION: Female pattern hair loss (FPHL) is a chronic, progressive condition that affects quality of life. Off-label systemic antiandrogens are increasingly used, but comparative data remain limited. METHODS: To compare the effectiveness, safety, and healthcare resource util...

Learning curve of Versius‐assisted radical prostatectomy: role of prior experience and proctoring

Objective To assess the learning curve for radical prostatectomy (RP) with the Versius system (CMR Surgical, Cambridge, UK) and evaluate the transfer of skills from previous robotic and laparoscopic practice. Subjects, Patients and Methods This prospective cohort study included p...

Return on investment in workplace health prevention and promotion: a systematic review (2003–2024)

Workplace health prevention and promotion (WHP) programs represent a strategic investment in human capital. Despite a growing body of evidence, synthesized economic evidence remains fragmented. This systematic review addresses identified gaps in the literature by synthesizing eco...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...