Hospital Universitario de La Princesa

Conscientious objection to euthanasia: a qualitative study of palliative care physicians’ perceptions

Abstract Background Conscientious objection (CO) in healthcare is a pressing issue, particularly in euthanasia, where legal permissibility coexists with moral disagreement. CO is commonly framed as a principled refusal based on moral or religious convictions, often emphasizing te...

Effectiveness of interleukin (IL)-23 and IL-12/23 inhibitors and factors associated with response in psoriatic arthritis with axial involvement: the APxis-IL12-23 study

OBJECTIVES: To assess the real-world effectiveness of two interleukin (IL)-23 inhibitors [guselkumab (GUS), risankizumab (RIS)] and an IL-12/23 inhibitor [ustekinumab (UST)] in patients with purely axial psoriatic arthritis (PsA) or mixed PsA (both axial and peripheral involvemen...

Molecular characterization of tetraploid astrocytes in drug-resistant temporal lobe epilepsy

Epilepsy is one of the most prevalent neurological diseases, with 25–33% of patients developing drug-resistant epilepsy (DRE). The precise etiology of DRE remains unidentified. Recent studies have revealed an increase in tetraploid astrocytes in drug-resistant temporal lobe epile...

Validation of plasma core biomarkers of Alzheimer's disease: A multicenter study in usual practice conditions

Background The new anti-amyloid therapies have brought the challenge of early and feasible identification of Alzheimer's disease (AD). Plasma biomarkers are promising tools, but real-world evidence remains limited. Objective We aimed to evaluate the diagnostic performance of plas...

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

Abstract Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I 3 LUNG ( NCT05537922 ) is currently the...

Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement

BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...

Working conditions and mental health among doctors and nurses in the European Union, Iceland, and Norway: a cross-sectional survey

Background Europe faces persistent challenges in retaining and recruiting healthcare workers. Poor working conditions and deteriorating wellbeing may contribute to attrition and turnover intentions, yet large-scale studies examining associations between working conditions and men...

Variability in the Application and Principles of Prehabilitation and Enhanced Recovery (VAPPER Survey) Among Colorectal Surgery Units: A National Multicentre Survey

Background: Prehabilitation has become an essential component of perioperative care in colorectal surgery, aiming to improve postoperative outcomes through multimodal interventions. However, its real-world implementation remains heterogeneous. This study aimed to evaluate the deg...

Treatment-free remission after bosutinib discontinuation (BOSUTFR): results from a multicenter real-world study by the Spanish CML group

Treatment-free remission (TFR) is an established therapeutic goal for patients with chronic myeloid leukemia (CML) achieving sustained deep molecular response (DMR) on tyrosine kinase inhibitors (TKIs). However, evidence on TFR following bosutinib discontinuation remains limited....