Hospital Universitário da Universidade de São Paulo

Time-Resolved Synchrotron-Based Investigation of Reactive Pore Evolution in Sandstone for CO 2 Storage

Abstract Understanding mineral dissolution in heterogeneous porous media is critical for predicting the evolution of subsurface systems during geological CO2 storage. Here, we integrate time-resolved synchrotron techniques, 4D X-ray microtomography (μ-CT), X-ray fluorescence (TR-...

Pharmacological prophylaxis for venous thromboembolism in hospitalized surgical patients at a secondary teaching hospital: a best practice implementation project.

INTRODUCTION: Thromboprophylaxis reduces venous thromboembolism (VTE) in hospitalized patients. However, despite robust evidence, financial constraints, structural barriers-including limited access, socioeconomic inequalities-alongside patient complexity and diagnostic challenges...

Physical therapy care utilization and associated sociodemographic and clinical factors among noncommunicable diseases in the brazilian population: A cross-sectional, population-based study

INTRODUCTION: Noncommunicable diseases (NCDs) are currently the leading cause of disability worldwide. In Brazil, NCDs are among the top 10 causes of disability-adjusted life years (DALYs). A better understanding of the profiles of patients who frequently use physical therapy is...

Schools as youth-friendly climate shelters: co-designing socio-spatial infrastructures of care for urban heat adaptation

Urban heat is unevenly distributed, while adaptation often overlooks young people’s lived experiences. This study examines how embodied and emotional experiences, everyday spatial practices, and participatory co-design inform youth-friendly climate shelters as socio-spatial infra...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Multifunctional NaNbO3: Photocatalytic Degradation of Methylene Blue and Intrinsic Antimicrobial Activity against Enterococcus faecalis and Candida albicans

Abstract In this paper, sodium niobate (NaNbO3) was synthesized by the microwave-assisted hydrothermal method at 150 °C for 70 min, followed by calcination at 550 °C for 2 h. X-ray diffraction revealed the coexistence of orthorhombic P21ma and Pbma phases, while scanning electron...

Assessment of organizational readiness for implementing an online pain education program for chronic musculoskeletal pain in Brazilian public health context: a cross-sectional study

Understanding the organizational readiness for behavior change is paramount for implementation success of new interventions and to avoid waste of resources. To assess organizational readiness of primary healthcare providers to refer users with chronic musculoskeletal pain for an...

Noninvasive or minimally invasive neuromodulation in animal models of acute ischemic stroke: A systematic review and meta‐analysis

Abstract Background Neuromodulation therapy has emerged as a potential brain cytoprotective strategy in the hyperacute phase of ischemic stroke (IS). This systematic review aimed to evaluate the cytoprotective effects of neuromodulation in animal models of IS. Methods A systemati...

Postharvest Quality and Functional Stability of White-Fleshed Sweet Potatoes with Cactus Mucilage Coatings and Packaging

Abstract Edible coatings based on plant-derived biopolymers are promising tools to preserve the functional quality of fresh foods. Sweet potato is considered a functional food due to its bioactive compound content, although these attributes may be compromised during postharvest s...

Beyond Closed-Shell Photochemistry: Singlet Oxygen Generation Driven by 10H-Phenothiazine Radical Cation

Abstract Phenothiazines are widely studied as closed-shell photosensitizers; however, their open-shell oxidized forms remain largely unexplored in photochemical contexts. Here, we investigate the photophysics and reactivity of the radical cation of 10H-phenothiazine (PHT•+) using...

Evolutionary Dynamics-Aware De Novo Design of a Thermostable NS1-Derived Diagnostic Protein for Yellow Fever Virus

Abstract Serological diagnosis of neglected arboviruses remains hindered by extensive intra-genus cross-reactivity, compromising both assay specificity and epidemiological accuracy. In this study, we focused on yellow fever virus (YFV) as a model system to design and validate a g...

Factors associated with discordance between the patient-reported Rheumatoid Arthritis Disease Activity Index (RADAI) and the Simplified Disease Activity Index (SDAI) concerning the achievement of treat-to-target goals – data from the REAL study

Abstract Background Treat-to-target (T2T) strategies in rheumatoid arthritis (RA) rely on regular assessment of disease activity using validated composite indices, with remission or low disease activity as therapeutic goals. The Simplified Disease Activity Index (SDAI) is widely...

Speech Outcomes After Primary Palatoplasty With Intravelar Veloplasty and Extensive Muscle Dissection: A Single-Surgeon Cohort Study

This retrospective single-surgeon cohort study evaluated speech outcomes in 79 children with nonsyndromic cleft palate, with or without cleft lip, who underwent primary palatoplasty with intravelar veloplasty involving extensive palatal muscle dissection, performed by a single su...

Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathways

Abstract COVID-19 and obesity are complex conditions marked by immune and metabolic dysfunction, with the former still ranking among the leading causes of death from infectious diseases worldwide and the latter reaching pandemic proportions. Clinical evidence consistently shows t...

Assessing iron, zinc and calcium bioaccessibility using the INFOGEST method: Challenges and opportunities

Abstract Iron, zinc and calcium are essential minerals required for key physiological functions, including oxygen transport, immune function, enzymatic activity and bone health. Despite their importance, deficiencies remain widespread globally, driven in part by the poor bioavail...

Endovascular therapy versus best medical treatment in pediatric acute ischemic stroke: A systematic review and meta-analysis

Purpose This systematic review and meta-analysis evaluates endovascular therapy (EVT) versus best medical treatment (BMT) in pediatric acute ischemic stroke (AIS) due to large-vessel occlusion. Methods Systematic searches were conducted across PubMed, Cochrane, and Embase, incept...

Common pathways and outliers in glucose catabolism across Trypanosomatidae

Glucose catabolism in trypanosomatids differs significantly from that in most other eukaryotes. Here, the first few enzymes of the pathway are all located inside glycosomes, that is, the peroxisome‐like microbodies uniquely present in the Kinetoplastida and Diplonemida of the Eug...

Relationship Between Nursing Diagnoses, Mortality and Length of Stay in the ICU: A Retrospective Cohort Study

ABSTRACT Background Nursing process is a systematic, problem‐solving framework structuring clinical reasoning and patient‐centred care; within it, Nursing Diagnoses (ND) link clinical assessment to planning and implementing individualised interventions. However, evidence demonstr...

Social cues on stone tools outweigh raw material properties in wild primates

1. Abstract The ability to select appropriate tool material enabled early hominins access to new resources and environments. The underlying mechanisms driving tool selection effectively remain unknown. Observations of extant primates have demonstrated strong selectivity for speci...