Hospital Universitari Joan XXIII de Tarragona

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Generalization, Cross-ICU Transfer, and Explainability of a Mortality and Time-to-Discharge Framework for the Intensive Care Unit

Background: PADS combines two neural networks predicting ICU mortality and discharge within 48 h, placing critically ill patients into one of four clinically meaningful states. Developed on MIMIC-IV alone, it left open whether it generalizes to other ICUs, whether its models tran...

Pedal Arch Integrity is Independently Associated With Limb Salvage in Chronic Limb-Threatening Ischemia With Isolated Peroneal Artery Runoff

Background: Although current revascularization paradigms emphasize direct inline flow through the target arterial pathway (TAP), the prognostic importance of distal pedal connectivity in this anatomical setting remains uncertain. Methods: Clinical, anatomical, procedural, and fol...

Elucidating the mechanism underlying incomplete immune recovery in people living with HIV through CD4⁺ and CD8⁺ T cell multi-omics

A subset of people living with HIV (PLHIV), known as immunological non-responders (INR), fails to achieve adequate CD4⁺ T cell recovery despite viral suppression with antiretroviral therapy (ART). These individuals face an increased risk of adverse clinical outcomes. This study a...

The first 72 hours of acute pancreatitis: patterns of variability in early clinical decision-making

To assess real-world adherence to evidence-based international guidelines in the early management of acute pancreatitis (AP), and to identify how variability in clinical decision-making is distributed during the first 72 h of care. This multicentre, cross-sectional survey was con...