Hospital Universitari Germans Trias i Pujol

The Influence of Culture on the Childbirth Experience: A Comparative Study of Women From Muslim and Christian Backgrounds

BACKGROUND: Childbirth is one of the most significant experiences in a woman's life, shaped by personal, healthcare, and cultural factors. It is widely recognized as a key indicator of obstetric care quality and woman-centered approaches. This study aimed to compare childbirth ex...

Design and validation of a GMP-compliant manufacturing platform of extracellular vesicles from mesenchymal stromal cells

There is growing interest in mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) as key components in the development of next-generation regenerative cell-free therapies; however, their clinical translation remains limited by a lack of validated clinical-grade manuf...

Effectiveness of interleukin (IL)-23 and IL-12/23 inhibitors and factors associated with response in psoriatic arthritis with axial involvement: the APxis-IL12-23 study

OBJECTIVES: To assess the real-world effectiveness of two interleukin (IL)-23 inhibitors [guselkumab (GUS), risankizumab (RIS)] and an IL-12/23 inhibitor [ustekinumab (UST)] in patients with purely axial psoriatic arthritis (PsA) or mixed PsA (both axial and peripheral involvemen...

Radiomics and artificial intelligence in pituitary adenomas (PitNETs): from imaging biomarkers to clinical translation

Abstract Pituitary neuroendocrine tumors (PitNETs) are common intracranial neoplasms with heterogeneous hormonal activity, invasiveness, and treatment response. Conventional MRI is central to diagnosis, but is limited in quantifying tumor heterogeneity and predicting clinically r...

Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement

BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

Modern endoscopic strategies for the diagnosis and management of cholangiocarcinoma

Cholangiocarcinoma (CCA) presents considerable diagnostic and therapeutic challenges for the endoscopist. This review offers a focused and practical evaluation of contemporary endoscopic approaches for the diagnosis and management of CCA, with an emphasis on real-world applicabil...

Prevalence and Predictors of Mechanical Restraint in Involuntary Patients in an Open-Door Inpatient Psychiatric Unit

Abstract Purpose Mechanical restraint (MR) remains one of the most controversial interventions in psychiatry, particularly in involuntarily admitted patients. This study examined the prevalence and clinical predictors of MR in an open-door psychiatric unit in Spain, a context whe...

Healthcare providers’ perspectives on physical activity in patients with heart failure and gender-related differences.

Objectives Physical activity (PA) is widely recognized as an effective intervention for patients with heart failure (HF). PA leads to significant improvements in outcomes such as aerobic capacity, quality of life, and cardiac function, which are linked to reduced hospitalizations...