Hospital Universitari de Girona Doctor Josep Trueta

Perinatal Outcomes and Determinants of Elective Embryo Reduction in Trichorionic Triplet Pregnancies

ABSTRACT Objective To evaluate whether elective embryo reduction (ER) reduces maternal obstetric complications in trichorionic triamniotic triplet pregnancies, to identify the maternal characteristics associated with the decision to undergo ER and its extent, and to describe asso...

Targeted DNA Sequencing Reveals Distinct Rare-Variant Profiles in Pulmonary Hypertension Associated with Chronic Lung Diseases

The mechanisms underlying the development and severity of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) remain poorly understood. To investigate the contribution of genetic factors, we performed targeted sequencing...

Phytate and L-methionine for preventing recurrence of infection renal stones

BACKGROUND: Urine acidification and inhibition of crystallization are strategies that can be employed to prevent recurrent infection stones and calcium phosphate stones. METHODS: A series of cases demonstrating the beneficial effects of treatment with phytate and L-methionine in...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Circle of Willis-Guided Localization for Simultaneous Detection and Classification of Large Vessel Occlusions in Brain CTA

Abstract Large vessel occlusions (LVOs) are blockages in the brain’s major arteries that can cause severe neurological damage. Rapid and accurate detection using computed tomography angiography (CTA) is critical for timely stroke treatment. Here, we present a fully automated appr...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Rescue transseptal percutaneous mitral balloon valvuloplasty for early bioprosthetic mitral valve thrombosis during VA-ECMO support: a case report

Abstract Background Early bioprosthetic mitral valve thrombosis (BPVT) is a rare but life-threatening cause of acute prosthetic obstruction after mitral valve surgery. Management is particularly challenging in postcardiotomy shock requiring veno-arterial extracorporeal membrane o...

Ultraslow brain dynamics as neurophysiological markers of information sampling during learning

To learn, we must actively sample information from our environment: selecting, prioritizing, and extracting relevant cues. Here, we investigated whether ultraslow event-related potentials (ERPs) could track information sampling as participants learned new words from sentence cont...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...