Hospital Tuanku Ja’afar

Safety and efficacy of non-medical switch from innovator to generic tofacitinib: a 3-month observational study in rheumatoid arthritis patients

Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation. Following the expiry of the patent for innovator tofacitinib (Xeljanz), generic tofacitinib formulations such as Tozib have become available. This study evaluated the impact of...

One Substitution, Four Degrees, and the Number That Stops Them

Textbooks present the solution of algebraic equations as four unrelated stories. We show that a single substitution, x = w - c/w with c = p/n, together with a single target, the Dickson polynomial equation, accounts for all of them. Bringing an arbitrary equation of degree n to t...