Hospital Ruber Internacional

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Interictal electric source imaging with open‐source software and routine low‐density electroencephalography: A systematic comparison of four inverse methods in drug‐resistant epilepsy

Abstract Objective This study was undertaken to assess the diagnostic accuracy of interictal electrical source imaging (ESI) performed using open‐source software and routine low‐density electroencephalography (LD‐EEG), comparing four inverse methods at two spike time points. Meth...

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...