Hospital of Hebei Province

Evaluation of the efficacy of oral propranolol combined with pulsed dye laser versus monotherapy with oral propranolol in the treatment of mixed infantile hemangiomas

Oral propranolol is first-line for problematic infantile hemangiomas (IHs) but often leaves superficial residual lesions. This study assessed the efficacy and safety of adding pulsed dye laser (PDL) to propranolol versus propranolol alone for mixed IHs. This single-center retrosp...

Exosomes From Cancer‐Associated Fibroblasts Suppress Ferroptosis and CD8 + T Cell Effector Function in Gastric Cancer via miR ‐4435/ NDUFA10 Axis

ABSTRACT Cancer‐associated fibroblasts (CAFs) are pivotal stromal component in tumor microenvironment (TME) and participate in regulating tumor development and progression via exosomes (exos) mediated intercommunication. However, the intricate mechanism underlying the exosomal mi...

Identification and expression validation of key genes of Xiaozhengtongluo formula in the treatment of diabetic nephropathy by Mendelian randomization

Xiaozhengtongluo formula (XZTL) has a positive effect on the treatment of diabetic nephropathy (DN), but its mechanism is not fully understood. Therefore, it is important to explore the key genes of XZTL in the treatment of DN. Differentially expressed genes (DEGs) between DN and...

Biomechanical advantages of the proximal femoral bionic nail with triangular support structure in the treatment of intertrochanteric fractures: a coronal fracture heatmap modeling and finite element comparison of three implant designs

Coronal fracture fragments (CFs) are highly prevalent in intertrochanteric fractures and represent a significant risk factor for internal fixation failure. This study combined anatomical and engineering approaches to construct the first coronal fracture heatmap model and evaluate...

Molecular and clinical characterization of human adenovirus in hospitalized pediatric respiratory infections: a five-year study

Abstract Background Human adenovirus (HAdV) is a major pathogen of responsible for respiratory tract infections (RTIs) in children in China. This study analyzed clinical data from hospitalized pediatric HAdV infections over a five-year period to characterize the epidemiology, cli...

MicroRNA-205-5p: a candidate biomarker and mechanistic mediator in polycystic ovary syndrome

The objective of this study was to investigate the impact of microRNA-205-5p (miR-205-5p) on clinical outcomes in patients with polycystic ovary syndrome (PCOS). Eighty PCOS patients and sixty-five healthy individuals were enrolled in this retrospective study. Serum levels of miR...

LINC01446/miR-338-3p/APEX1 Axis Promotes Ferroptosis Defense and Progression in Esophageal Squamous Cell Carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a poor prognosis, highlighting the urgent need to elucidate its molecular mechanisms to develop targeted therapies. Long non-coding RNAs (lncRNAs) play a critical role in cancer progression. Ho...

Esketamine induces ferroptosis and suppresses immune evasion in lung adenocarcinoma cells via the hsa_circ_0022392/miR-548b-3p/MAP7 axis

Abstract Background Although Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used for anesthesia and analgesia and has shown anticancer activity, its effects on lung adenocarcinoma remain unclear. Circular RNAs have been implicated in the development and...