Hospital Juan Ramón Jiménez

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...

Association Between the GMI / HbA1c Ratio and Microvascular Complications in Type 1 Diabetes: A Multicenter Cross‐Sectional Study

ABSTRACT Objective To clarify whether the glucose management indicator (GMI)/glycated haemoglobin (HbA1c) ratio (GMI/HbA1c ratio) is an independent predictor of microvascular complications in Type 1 diabetes (T1D). Design and Methods Multicentre, cross‐sectional, observational st...

Impulsivity in cluster headache: a case–control genetic association study

Impulsivity has received limited attention in cluster headache (CH), despite growing evidence of a broader behavioral phenotype in the disorder. We aimed to compare impulsivity between patients with CH and healthy controls and to explore associations between selected candidate ge...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Malnutrition Severity, Morphofunctional Assessment, and Survival in Patients with Lung Cancer: A Multicentre Prospective Cohort Study

PURPOSE: Malnutrition is common in lung cancer and may contribute to impaired functional status and poor survival. This study evaluated the association between GLIM-defined malnutrition, morphofunctional nutritional parameters, and one-year mortality in patients with lung cancer....

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...

Late prolonged cardiac monitoring after cryptogenic ischemic stroke using a textile wearable Holter

Subclinical atrial fibrillation is a leading underlying cause of cryptogenic stroke. Early prolonged cardiac monitoring is recommended, yet timely access is often limited. We evaluated the performance and therapeutic implications of prolonged cardiac monitoring using the NUUBO ®...