Hospital Israelita Albert Einstein

Photobiomodulation to minimize talquetamab-associated dysgeusia and xerostomia in multiple myeloma: a brief report of four cases

BACKGROUND: Talquetamab, a GPRC5D-targeting bispecific antibody, produces high response rates in relapsed/refractory multiple myeloma (RRMM) but is frequently associated with oral adverse effects, most commonly dysgeusia and xerostomia, which can impair nutrition and quality of l...

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

Evidence to guide the treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with...

Sexual dimorphism in fetal brain gene co-expression networks as a possible etiological factor of sex-biased autism prevalence

Autism spectrum disorder (ASD) affects more males than females in an approximate ratio of 4:1, yet the biological bases of this imbalance remain unclear. Here, we explored the hypothesis that part of the male-biased vulnerability could arise from sex-specific baseline organizatio...

Routine MRI for opportunistic osteoporosis screening: diagnostic accuracy of vertebral bone quality and a novel femoral bone quality score compared with DXA

OBJECTIVES: To evaluate vertebral bone quality (VBQ) and femoral bone quality (FBQ) scores as potential imaging markers of bone mineral density (BMD) for opportunistic osteoporosis screening in at‑risk patients and to assess their correlation with DXA T-scores. METHODS: This retr...

Breast reconstruction and breast cancer surgery in Brazil’s public health system: a nationwide interrupted time-series analysis, 2008–2024

Abstract Background Breast reconstruction is a key component of comprehensive breast cancer care, yet access remains uneven in many middle-income countries. In Brazil, federal policies have sought to expand reconstruction within the public health system (SUS), but long-term natio...

A challenging case of Down syndrome regression disorder.

Abstract: Down syndrome regression disorder (DSRD) is a rare cause of neuropsychiatric regression observed in previously-healthy individuals with Down syndrome (DS). There have been reports of brain iron accumulation in the basal ganglia of patients with DS and DSRD, although the...