Hospital Israelita Albert Einstein

Dissociation Between Instrumented Mobility and Self-Reported Function in Adults Aged 70 Years or Older After Unilateral Total Knee Arthroplasty: A Preliminary Longitudinal Study Using an Inertial Sensor and the WOMAC

Background and Objectives: Total knee arthroplasty (TKA) reliably reduces pain and improves self-reported function, yet objective mobility may remain impaired in older adults. We examined the relationship between inertial-sensor-based mobility and the Western Ontario and McMaster...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

The cost of intensification in high-risk non–muscle-invasive bladder cancer

Non–muscle-invasive bladder cancer (NMIBC) is a common and costly disease that requires experienced teams and adequate infrastructure for its management. Although characterized by high rates of recurrence, a subset of patients also faces a substantial risk of progression to muscl...

Hospital wastewater-based antimicrobial resistance epidemiology: a scoping review

Abstract Introduction: Wastewater-based epidemiology (WBE) offers pooled biological samples of defined populations, complementing clinical surveillance for infectious diseases. Hospitals are hotspots for antimicrobial resistance (AMR). We performed a scoping review assessing hosp...

Photoresponsive Bilayer Coating Integrating a Porous Zinc Oxide Layer and a Chitosan–Antibiotic Drug Delivery System for Antimicrobial Photodynamic Therapy in Biomedical Implants

Abstract Peri-implant infections remain a major cause of implant failure, highlighting the need for antimicrobial implant surfaces capable of suppressing biofilm formation while preserving the physicochemical and biological features needed for osseointegration. Here, we engineere...

Differential associations between treatment delay and survival across head and neck cancer subsites: a national hospital-based framework for risk-stratified prioritization

Purpose Delays in time to treatment initiation (TTI) have been associated with inferior outcomes in head and neck cancer, yet prior studies have typically evaluated tumors collectively, assuming uniform time sensitivity across diseases. This study quantified subsite- and stage-sp...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial

Fluid resuscitation in early septic shock has a narrow therapeutic index. Signals of fluid intolerance are frequently present during early resuscitation, yet current resuscitation strategies do not incorporate them to guide when to limit fluid administration. We evaluated whether...

Photothrombotic Ischemic Stroke in Rats: A Systematic Review of Experimental Parameters and Therapeutic Applications in Neuroprotection, Neuromodulation, and Post-Stroke Recovery

Background/Objectives: This systematic review analyzed the experimental parameters of the photothrombotic ischemic stroke model in rats and their relationship with neuroprotection, neuromodulation, and post-stroke recovery studies. We examined the follow-up periods and the behavi...

Healthcare occupancy data as an early warning indicator of infectious disease surges in São Paulo

Early detection of infectious disease surges is critical for effective public health response, yet traditional surveillance systems often suffer from delayed reporting. Here, we investigate whether passively collected occupancy data from healthcare facilities can act as an early...

First Brazilian instrument for assessing patient engagement in patient safety: a cross-cultural adaptation and content validation study

Abstract Background Patient safety is highlighted as a global health challenge, requiring changes and the implementation of initiatives to minimize risks, prevent care failures, and avoid harm to patients. Patient engagement has been one of the most recommended strategies for imp...

Frailty assessed using the Edmonton Frail Scale predicts mortality and waitlist removal for kidney transplant candidates: a prospective study

Frailty is associated with adverse outcomes in kidney transplant (KT) candidates. The Edmonton Frail Scale (EFS) is a reliable tool to access frailty in a multidimensional approach. However, its prognostic association with outcomes in transplant waitlist remains unclear. Hence th...

Do Preoperative Glucagon-Like Peptide-1 Receptor Agonists Influence Lumbar Fusion Outcomes? A Systematic Review and Meta-Analysis

Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in patients with obesity and type 2 diabetes, but lumbar fusion-specific associations with postoperative outcomes remain uncertain. Objective To evaluate the association between preoperative GLP...

Minimally Invasive vs Open Surgery for the Treatment of Spinal Spondylodiscitis: A Systematic Review and Meta-Analysis

Background Despite common conservative management for spondylodiscitis, surgical intervention is indicated in specific clinical scenarios. While open techniques are traditionally favored, the role and efficacy of minimally invasive surgery (MIS) vs conventional open approaches re...

Power Profile of Olympic Cross-Country Mountain Biking: Durability Matters

Abstract Inoue, A, Mateo-March, M, Protzen, G, do Carmo, EC, Lattari, E, Costa, VP, and Bezerra da Silva, E. Power profile of Olympic cross-country mountain biking: Durability matters. J Strength Cond Res XX(X): 000–000, 2026—Power output decline may represent an important indica...

Light-Based Therapies for Metabolic Modulation of Mesenchymal Stem Cells in Regenerative Dentistry

Abstract Periodontal diseases and temporomandibular disorders are characterized by chronic inflammation and progressive destruction of supporting tissues, leading to functional and aesthetic impairments. In this context, regenerative dentistry has increasingly focused on minimall...

Interlaminar Contralateral Endoscopic Foraminotomy Reduces Postoperative Dysesthesia in Patients With Degenerative Lumbar Deformity: A Multicenter Comparative Cohort Study

Study Design Retrospective-prospective multicenter comparative cohort study. Objectives Postoperative dysesthesia (POD) is a recognized complication of transforaminal endoscopic lumbar surgery, with reported rates up to 21.5%. Degenerative lumbar deformity may amplify this risk t...

Ketamine for Analgosedation in Mechanically Ventilated Adults: A Double-Blind Randomized Trial

OBJECTIVES: The role of ketamine for analgosedation in the ICU remains unclear. This study aimed to assess the efficacy of low-dose ketamine infusion for adjunct analgosedation in adults receiving mechanical ventilation. DESIGN: A prospective, double blind, randomized, placebo-co...

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk

Abstract Background MetaboHealth represents a novel indicator of overall health in middle age and may potentially be suitable as actionable health check in prevention strategies. MetaboHealth is a blood-based metabolomic composite score that predicts a wide range of age-related c...