Hospital General Universitario Gregorio Marañón

Current Advances in the Medical Management of Stevens-Johnson’s Syndrome

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially life-threatening type IV immune reactions characterized by systemic inflammation mediated by cytotoxic T lymphocytes resulting in epidermal detachment and extensive necrosis. Although infrequent,...

Contraceptive use in women of childbearing age with bipolar disorder

INTRODUCTION: Unplanned pregnancies are frequent in women with bipolar disorder (BD) while perinatal period is associated with a higher risk of relapse. Effective contraception during childbearing age in BD could reduce the risk of unplanned pregnancy and its consequences. The pr...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Mental health disparities in LGBTQIA+ populations: an umbrella review of systematic reviews and meta-analyses.

Lesbian, gay, bisexual, transgender, questioning, intersex, asexual (LGBTQIA+) populations face unique social, political, psychological and health care-related challenges that contribute to marked mental health disparities. However, the overall strength and credibility of evidenc...

Intra-Articular Extra-Synovial Venous-Type Synovial Haemangioma of the Knee in a Young Adult: Case Report and Literature Review of This Frequently Misdiagnosed Lesion

Objective To report a rare lesion, an intra-articular extra-synovial venous-type synovial haemangioma of the knee in a young adult and to review the relevant literature on this frequently misdiagnosed entity. Case report A 21-year-old man presented with recurrent knee effusions a...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

Validation of plasma core biomarkers of Alzheimer's disease: A multicenter study in usual practice conditions

Background The new anti-amyloid therapies have brought the challenge of early and feasible identification of Alzheimer's disease (AD). Plasma biomarkers are promising tools, but real-world evidence remains limited. Objective We aimed to evaluate the diagnostic performance of plas...

Hypofractionation in Unresectable Stage II-III NSCLC: A Systematic Technical Review and Practical Recommendations

Background: Concurrent chemoradiotherapy (cCRT) followed by 1 year of consolidation durvalumab remains the standard of care for unresectable stage III non-small cell lung cancer (NSCLC), yet long-term survival is still limited and around 20% of patients present locoregional relap...

Patients’ and oncologists’ perspectives on shared decision-making and treatment communication in HR+/HER2 − advanced breast cancer: a multicountry survey

Hormone receptor–positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) breast cancer (BC) represents approximately 70% of all cases. In locally advanced or metastatic stages (laBC/mBC), patients’ quality of life (QoL) often worsens, making shared decision-maki...

Cilastatin versus sodium thiosulfate for prevention of cisplatin-induced acute kidney injury during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC): a randomized non-inferiority trial protocol

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS–HIPEC) using cisplatin is an established treatment for selected patients with peritoneal malignancies, but acute kidney injury (AKI) remains a common and clinically significant complication. Periop...

The Parkinsonian Motor Spectrum in Nonagenarians: A Population‐Based Study

BACKGROUND: Population-based data on mild parkinsonian signs (MPS) and parkinsonism in nonagenarians are scarce. OBJECTIVES: To estimate the prevalence of MPS, definite parkinsonism, and broader parkinsonian motor phenotypes; assess MPS after excluding idiopathic Parkinson diseas...

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study in...

Trop-2 overexpression as a prognostic marker in early triple-negative breast cancer: results from the GEICAM_CIBOMA trial

Trophoblast cell-surface antigen 2 (Trop-2) is a key therapeutic target in metastatic triple-negative breast cancer (TNBC), yet its prognostic significance in early-stage disease remains poorly defined. We evaluated Trop-2 expression and its clinical impact within a sub-cohort of...

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Association of blood-pressure time-in-therapeutic range with morbidity and mortality in hypertensive patients: a retrospective cohort study in the community setting

Abstract Background Hypertension is one of the leading modifiable risk factors for cardiovascular disease. This study assessed the association between good blood pressure control (GBPC), measured by time in therapeutic range (TTR) during the first year after hypertension diagnosi...

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...

Causes of death and mortality patterns in clozapine-treated patients: 17-year retrospective cohort study

Background Clozapine reduces overall mortality and suicide risk in schizophrenia, but the specific causes and clinical contexts of death among clozapine-treated patients remain less well characterised. Aims We aimed to characterise causes of death in clozapine-treated patients wi...

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

ABSTRACT Cells experience time‐varying mechanical cues when navigating complex microenvironments, yet whether and how they retain a short‐term memory of recent deformations remains unclear. Here, we show that glioblastoma cells encode such memory through transient cytoskeletal an...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...