Hospital General Universitario De Valencia

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...

Association Between the GMI / HbA1c Ratio and Microvascular Complications in Type 1 Diabetes: A Multicenter Cross‐Sectional Study

ABSTRACT Objective To clarify whether the glucose management indicator (GMI)/glycated haemoglobin (HbA1c) ratio (GMI/HbA1c ratio) is an independent predictor of microvascular complications in Type 1 diabetes (T1D). Design and Methods Multicentre, cross‐sectional, observational st...

Rapid FTIR-based serotyping of Streptococcus pneumoniae using the IR Biotyper: a comparative study against WGS and PCR-hybridization for clinical algorithm integration

ABSTRACT Serotyping of Streptococcus pneumoniae is essential for epidemiological surveillance and vaccine formulation. While the Quellung reaction remains the gold standard, it is limited by its technical demands and cost. Genomic approaches such as whole-genome sequencing (WGS)...

Radiofrequency Ablation for Interdigital Neuroma: Moderate 2-Year Outcomes and Surgical Conversion Rate

BACKGROUND: Radiofrequency ablation (RFA) has emerged as a minimally invasive alternative for the treatment of interdigital neuroma; however, evidence regarding its midterm effectiveness remains limited. The aim of this study was to evaluate midterm clinical outcomes following RF...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Trop-2 overexpression as a prognostic marker in early triple-negative breast cancer: results from the GEICAM_CIBOMA trial

Trophoblast cell-surface antigen 2 (Trop-2) is a key therapeutic target in metastatic triple-negative breast cancer (TNBC), yet its prognostic significance in early-stage disease remains poorly defined. We evaluated Trop-2 expression and its clinical impact within a sub-cohort of...

Butterfly gliomas of the corpus callosum: A systematic review of the literature

Objectives: Although rare, butterfly gliomas are notorious for their inferior clinical outcomes. The objective of the present study was to systematically review the available literature regarding the optimal management protocols and prognosis of butterfly glioma based on the avai...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...