Hospital General Universitario de Alicante Doctor Balmis

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...

Association Between the GMI / HbA1c Ratio and Microvascular Complications in Type 1 Diabetes: A Multicenter Cross‐Sectional Study

ABSTRACT Objective To clarify whether the glucose management indicator (GMI)/glycated haemoglobin (HbA1c) ratio (GMI/HbA1c ratio) is an independent predictor of microvascular complications in Type 1 diabetes (T1D). Design and Methods Multicentre, cross‐sectional, observational st...

Pre-implantation psychological assessment and two-year outcomes of spinal cord stimulation for chronic pain: a retrospective observational study

Abstract Background Chronic pain may improve with spinal cord stimulation (SCS), but whether pre-implantation psychological assessment carries prognostic value is unclear. We describe outcomes over two years following SCS implantation and tested whether the baseline MCMI-III prof...

Whole-genome sequencing of Reed-Sternberg cells identifies outcome determinants in Hodgkin lymphoma

Abstract Classical Hodgkin lymphoma (cHL) is a B-cell-derived malignancy characterized by rare Hodgkin and Reed–Sternberg (HRS) cells within an extensive inflammatory microenvironment. Although most patients achieve durable remission with first-line therapy, a subset relapse or e...

Tools for measuring quality of care in breast surgery

Breast cancer is the most common malignancy in women, and surgery remains a cornerstone of treatment. Traditional quality indicators, such as complication or margin status, often fail to capture the overall quality of surgical care. In recent years, indicators such as Textbook Ou...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...

Prevalence and incidence of dementia with Lewy bodies using current McKeith diagnostic criteria (2017–2020): a population-based study

Dementia with Lewy bodies (DLB) is one of the most common neurodegenerative dementias in older adults but remains frequently underdiagnosed in routine clinical practice. Epidemiological data are limited and heterogeneous, and only a small number of population-based studies have a...

Development and reproducible description of a multimodal physiotherapy intervention for pelvic floor health: a methodological report

Female pelvic floor disorders are frequently managed through interventions focused on pelvic floor muscle training (PFMT). However, pelvic floor function is increasingly recognised as being influenced by the interaction between breathing, posture, movement, and lumboabdominopelvi...