Hospital District of Helsinki and Uusimaa

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU ‐Funded Projects

Real-world data are increasingly important for regulatory and health technology assessment decision-making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe pr...

Age-based prognosis in oral tongue squamous cell carcinoma patients: A systematic review and meta-analysis

Abstract Background The prognostic significance of younger age in oral tongue squamous cell carcinoma (OTSCC) remains uncertain because age definitions, treatment strategies, outcome definitions, and adjustment methods vary substantially across studies. Objective To evaluate the...

Compensated Patient Injury Cases Due to Medication Errors in Finland During 2021 to 2023: A Cross-Sectional Register-Based Study

Objectives: To analyze follow-up data on medication errors (ME) in compensated patient claims in Finland from 2021 to 2023 and to discuss whether medication safety has improved since 2013 to 2014. Methods: This was a cross-sectional retrospective register-based study analyzing th...

Alcohol and other drug policies for health care workplaces: evaluation of the content, quality and implementability

Purpose Research on alcohol and other drug policies (AOD policies) at workplaces has been conducted mainly in the manufacturing industry and among general working population. There is a lack of research from health care workplaces. This study describes the content and evaluates t...

Craniofacial growth in Mulibrey nanism and impact of growth hormone treatment

Abstract Background Mulibrey nanism (MUL) impacts cellular metabolism and leads to severe prenatal onset growth restriction, distinctive craniofacial features, heart disease, hypogonadism, and predisposition to tumors. Growth hormone therapy is commonly used in treatment of patie...

Laparoscopic versus transvaginal mesh surgery in treatment of apical pelvic organ prolapse in women: MESH-study protocol for a randomized controlled trial

Lifetime risk for pelvic organ prolapse is 10–13%. As primary surgical treatment hysterectomy has been a common procedure, with or without colporrhaphies. The risk of recurrent apical prolapse is approximately 10%, and mesh surgery is often needed to gain sufficient support for t...

Interpretable multi-modal hierarchical framework to support cytomorphological analysis of hematologic cancers

Cytomorphological analysis of bone marrow aspirate (BMA) and peripheral blood smears (PBS) remains a diagnostic cornerstone in hematology. Machine-assisted analysis could support diagnostic workflows, but remains challenging due to the imbalanced prevalence of hematologic maligna...

Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

<title>Abstract</title> <bold>Purpose</bold> Methylprednisolone is commonly used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and procedural factors such as ci...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Expanding the cardiac phenotype of homozygous PPA2 variants: insights from a large Finnish family

Abstract Background Cardiomyopathies in children associate with significant morbidity and mortality. PPA2 deficiency is a rare mitochondrial disorder linked to sudden cardiac death in children and adolescents. Most reported cases are post-mortem, with limited data on surviving in...