Hospital del Mar Research Institute

METTL3-mediated m 6 A modification of DNMT1 enhances ovarian cancer progression

Abstract High-grade serous carcinoma (HGSC), the most lethal subtype of ovarian cancer, is often diagnosed at advanced stages owing to its asymptomatic progression and lack of early detection markers. In this study, we identified a critical oncogenic role of the RNA methyltransfe...

SANTBOISA cohort study protocol: lifestyle, socioeconomic, and environmental factors in paediatric obesity

Paediatric obesity is a major public health concern worldwide. Obesity during childhood or adolescence is associated with an increased risk of obesity and other health problems in adulthood. Studying its determinants is crucial for guiding structural and health promotion interven...

Prediction of high-flow nasal cannula failure in COVID-19 acute hypoxemic respiratory failure using combined clinical and metabolomic data: a machine learning study

Background High-flow nasal cannula (HFNC) is widely used as first-line non-invasive respiratory support in acute hypoxemic respiratory failure (AHRF), particularly during the COVID-19 pandemic. However, HFNC failure remains frequent, and delayed intubation is associated with wors...

EXPRESS: Multidomain determinants of perivascular spaces indicate early cerebrovascular vulnerability in individuals at risk of Alzheimer’s disease

BACKGROUND: Perivascular spaces (PVS) are MRI-visible markers of cerebrovascular and glymphatic function, but their regional determinants in preclinical Alzheimer's disease (AD), regarding sex and AD biomarkers, remain poorly understood. METHODS: We studied 1,199 cognitively unim...

Irreversible electroporation for liver metastases not amenable to conventional treatments, an experience with technical challenges, clinical outcomes, and complications

Irreversible electroporation (IRE) is a non-thermal ablation technique for perivascular liver tumors unsuitable for conventional thermal ablation due to heat-sink effects. This prospective, single-center, single-arm study (2020–2025) evaluated IRE in 14 patients with 16 anatomica...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trial

Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-term, multicomponent weight-loss programmes remains unclear. This study evaluated the impact of an i...

Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

Abstract Gastrointestinal (GI) symptoms are prevalent in Autism Spectrum Disorder (ASD), yet their biological correlates remain poorly understood, notably in adults. The microbiota-derived metabolite p- cresol is reported to be elevated in the urine and stool of ASD patients, but...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Clinical and Radiological Outcomes of Organising Pneumonia Secondary to COVID-19: A 2-Year Longitudinal Cohort Study

Background: Organising pneumonia secondary to COVID-19 (OP-COVID-19) is a recognised inflammatory complication of SARS-CoV-2 infection. We assessed the 2-year clinical, radiological, and functional evolution of patients hospitalised with OP-COVID-19 and identified factors indepen...

A cluster-randomized controlled trial of a family-based psychosocial intervention to prevent childhood obesity from preschool ages: the PRESAFALIN study protocol

Abstract Background: Childhood obesity is a major global concern, and Spain's high obesity rates highlight the urgent need for effective and innovative interventions in early age. The PRESAFALIN study aims to promote parental competence, self-efficacy, and resilience to improve c...