Hospital de Santo António

Navigating Uncharted Waters: Steering the Course and Confronting Challenges of Brain Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Brain metastases represent a major clinical challenge in the management of non-small-cell lung cancer, particularly in patients with epidermal growth factor receptor mutations, constituting a leading cause of morbidity and mortality. In recent years, significant advancements have...

An in-depth comparison: first wave of mpox in Rio de Janeiro, Brazil and Lisbon, Portugal

Abstract Background The 2022 mpox outbreak spread rapidly beyond endemic regions, affecting multiple countries with broadly similar transmission patterns but different public health responses and surveillance systems. We compared laboratory-confirmed mpox infections reported duri...

Untargeted 1H-NMR metabolomics of bronchoalveolar lavage fluids to identify biomarkers for early diagnosis of lower respiratory tract infections

Lower respiratory tract infections (LRTIs) remain a leading cause of death worldwide. Their complex clinical presentation underscores the need for accurate, timely laboratory diagnosis; however, reliable diagnostic biomarkers are still lacking. We performed untargeted 1 H-NMR met...