Hospital de Santo António

Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...

Orthopaedic Management of Bone Metastases from Lung Cancer

Background/Objectives: Bone metastases from lung cancer can cause pain, pathological fracture, spinal instability, metastatic spinal cord compression and loss of independence. Lung cancer-specific evidence for orthopaedically relevant local management remains fragmented. This rev...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Effectiveness of interventions to prevent or treat prolonged grief symptoms among families of the patients who die in intensive care units: A systematic review and meta-analysis

Background Family members of ICU decedents are at high risk of adverse psychological outcomes, including prolonged grief. However, evidence regarding the effectiveness of existing family support interventions remains limited. Objectives To evaluate the effectiveness of interventi...

Central nervous system manifestations in hereditary transthyretin amyloidosis: a cross-sectional study with 151 patients

Abstract Background Central nervous system (CNS) dysfunction is increasingly recognized in hereditary transthyretin (ATTRv) amyloidosis. We aimed to characterize CNS manifestations and assess associations with clinical variables and plasma neurofilament light chain (NfL), using h...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Navigating Uncharted Waters: Steering the Course and Confronting Challenges of Brain Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Brain metastases represent a major clinical challenge in the management of non-small-cell lung cancer, particularly in patients with epidermal growth factor receptor mutations, constituting a leading cause of morbidity and mortality. In recent years, significant advancements have...

An in-depth comparison: first wave of mpox in Rio de Janeiro, Brazil and Lisbon, Portugal

Abstract Background The 2022 mpox outbreak spread rapidly beyond endemic regions, affecting multiple countries with broadly similar transmission patterns but different public health responses and surveillance systems. We compared laboratory-confirmed mpox infections reported duri...

Untargeted 1H-NMR metabolomics of bronchoalveolar lavage fluids to identify biomarkers for early diagnosis of lower respiratory tract infections

Lower respiratory tract infections (LRTIs) remain a leading cause of death worldwide. Their complex clinical presentation underscores the need for accurate, timely laboratory diagnosis; however, reliable diagnostic biomarkers are still lacking. We performed untargeted 1 H-NMR met...