Hospital de Clínicas Universidade Federal do Paraná

Trichoblastic Carcinoma Arising Within a Trichoepithelioma: A Biphasic Follicular Neoplasm With Compartment-Specific CK15, CK20, and Ki-67 Findings

Abstract: Trichoblastic carcinoma (TBC) is a rare malignant follicular neoplasm whose distinction from trichoblastoma/trichoepithelioma (TE) and basal cell carcinoma may be challenging. We report an 83-year-old woman with a nodule on the left superior parietal scalp suspected cli...

Task force of the Brazilian Society of Otology and the Brazilian Academy of Neurotology: Menière’s Disease

Objective To critically review the available evidence on the pathophysiology and diagnosis of Menière’s disease and to provide consensus-based recommendations developed by a task force of the Brazilian Society of Otology and the Brazilian Academy of Neurotology. Methods A task fo...

Laboratory Testing at the End of Life in Patients With Cancer: A Systematic Review of Utilization, Costs, Clinical Utility, and Patient Burden

Background Laboratory tests can identify reversible causes of distress near the end of life, but how often they are ordered does not by itself show whether they improve care. Objective To synthesize evidence on laboratory testing near the end of life in cancer, including utilizat...