Hospital de Clínicas "José de San Martín"

Cycling Versus Swapping After First-Line TNF Inhibitor Failure in Psoriatic Arthritis: Real-World Insights From the Argentine RECCAPSO Registry

Objectives: Cycling within the same mechanism of action (MoA) or swapping to a different MoA are 2 strategies after failure of advanced therapy in psoriatic arthritis (PsA). We described the frequency, clinical characteristics, and treatment trajectory of cycling versus swapping...

Mitochondrial Dysfunction Markers in Paediatric Obesity: DNA Content and Oxidation Damage

ABSTRACT Background Childhood obesity increases chronic disease risk. Mitochondrial dysfunction, reflected by altered mitochondrial DNA (mtDNA) content and oxidative damage, has been implicated in obesity‐related metabolic disorders, but paediatric data remain scarce. Objective T...

Angiotensin II and cAMP signaling pathways regulate mitochondrial biogenesis and activity in human adrenocortical cells

Abstract Mitochondrial homeostasis, governed by the balance between biogenesis and mitophagy, is essential for steroidogenesis in adrenocortical cells. While the requirement of active mitochondria for steroid synthesis is well-established, the hormonal regulation of genes governi...

The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection

ABSTRACT Background Chronic respiratory diseases impose a large global burden of morbidity, mortality, and cost. The concept of a global airway has become increasingly supported by epidemiologic, mechanistic, and clinical evidence. However, clinical care often remains fragmented...

Smart Lithotripsy: Lasers, Energy Sources and Efficiency

PURPOSE OF REVIEW: To examine the evidence on contemporary lasers and provide a practical framework for platform selection, parameter optimization, and thermal safety based on the principles of smart lithotripsy. RECENT FINDINGS: Holmium: yttrium-aluminum-garnet (Ho:YAG) remains...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...