Hospital de Clínicas de Porto Alegre

Task force of the Brazilian Society of Otology and the Brazilian Academy of Neurotology: Menière’s Disease

Objective To critically review the available evidence on the pathophysiology and diagnosis of Menière’s disease and to provide consensus-based recommendations developed by a task force of the Brazilian Society of Otology and the Brazilian Academy of Neurotology. Methods A task fo...

Clozapine Across Treatment-Resistant Symptom Dimensions: A Conceptual Review and Transdiagnostic Rationale for Child and Adolescent Psychiatry

Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, yet in children and adolescents it remains off-label and underused, constrained by safety concerns and scarce pediatric-specific evidence. Its benefits may extend beyond any single diagnostic cat...

Systematic Review and Meta-analysis of Prevalence of Mental Disorders and Suicidality Among Children and Adolescents Living with HIV in South Africa

Abstract Despite progress in HIV prevention and treatment, global data suggests that youth living with HIV remain at risk of mental disorders and suicidality. However, reliable epidemiological data from South Africa (SA) are limited. We conducted a systematic review and meta-anal...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Behavioral, Psychological, and Metabolic Characteristics of Adults with Co-Occurring Generalized Anxiety Disorder and Obesity: A Cross-Sectional Study

Background: Generalized Anxiety Disorder (GAD) and obesity are highly prevalent and often co-occur, yet it remains unclear how the presence of both conditions relates to biological, behavioral, and psychological outcomes compared with either condition alone. Understanding this su...

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone remains limited. Objective Given the role of the gut microbiome in disease progression, we evaluated whether gut metagenomic profiles are associated with 90-...

Evaluation of in vitro activity of delafloxacin against Staphylococcus aureus MSSA and MRSA isolated from a Brazilian tertiary hospital

Abstract Introduction Proper treatment for infections caused by Staphylococcus aureus , particularly methicillin-resistant strains (MRSA), remains a constant challenge in hospital settings. In this context, the search for new antimicrobials, such as delafloxacin, has become neces...

Probiotics and intestinal permeability in adults with metabolic dysfunction‐associated steatohepatitis: A secondary analysis of a randomized clinical trial

Abstract Background Metabolic dysfunction‐associated steatohepatitis (MASH) is associated with altered intestinal permeability, allowing microbial products to translocate to the liver via the enterohepatic circulation and contributes to disease progression. The aim of our study w...

L-carnitine modulates molecular responses associated with inflammation, endoplasmic reticulum stress, and neurotrophic signaling in cerebral cortex of neonatal Gcdh−/− mice exposed to glutaric and quinolinic acids

Abstract Glutaric acidemia type 1 (GA I) is caused by deficient activity of glutaryl-CoA dehydrogenase, leading to predominant accumulation of glutaric acid (GA) in the brain. GA I patients present progressive neurological deterioration whose pathophysiology is only partially elu...

Self-report instruments for assessing transference in psychoanalytical research: a neglected or avoided concept? - A systematic review

Transference is defined as the possibility for the patient to relive, during the psychotherapy process, unconscious impulses and fantasies awakened in the relationship with a person from the patient’s earlier life and it plays an essential role in psychoanalytic treatments. This...

Glucose Transporter Deficiency Syndrome Type 1 (Glut1‐ DS ): New Insights From a Brazilian Cohort of Patients

ABSTRACT Glucose transporter deficiency syndrome type 1 (Glut1‐DS) is a rare neurometabolic disorder caused by pathogenic variants in SLC2A1 , characterized by epilepsy, neurodevelopmental delay, movement disorders, dysarthria, intellectual disability, and postnatal microcephaly....

Is self-reported daylight exposure reliable? A validation study with actigraphy in urban environments

Daylight exposure is an environmental determinant of human health, yet measuring real-world exposure at scale remains a major challenge. Large population studies frequently rely on self-reported time spent outdoors as a proxy for daylight exposure, although the validity of this m...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...