Hospital das Clínicas da Universidade Federal de Pernambuco

Upregulation of cellular exhaustion-related genes and CD4 + T cell disturbances in immunological non-responders on antiretroviral therapy

Abstract Antiretroviral therapy suppresses HIV replication, but 10–40% of people living with HIV do not reconstitute CD4 + T cell counts despite viral suppression. Cellular exhaustion and alteration in the frequency of CD4 + T cell subsets are mechanisms involved in immunological...

Proposal for a new standard area diagram to quantify the severity of orange rust in sugarcane

Orange rust (Puccinia kuehnii), a fungal disease of major concern in the sugarcane industry, can reduce the productivity of susceptible sugarcane varieties by up to 50% in many sugarcane-producing countries. The use of a standard area diagram (SAD) enhances the assessment of rust...

Economia ecológica: uma possível referência para o desenho de sistemas humanos realmente sustentáveis

In the prevailing model of the typical economist, the economy is seen as an isolated system, without an environment, ignoring the ecosystem, the biophysical framework of the real economic system. It ignores the importance of happiness for social life as well. In fact, people are...

A challenging case of Down syndrome regression disorder.

Abstract: Down syndrome regression disorder (DSRD) is a rare cause of neuropsychiatric regression observed in previously-healthy individuals with Down syndrome (DS). There have been reports of brain iron accumulation in the basal ganglia of patients with DS and DSRD, although the...