Hospital da Luz

Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...

Longitudinal changes in social cognition in early relapsing-remitting multiple sclerosis over two years

Longitudinal studies examining social cognition in multiple sclerosis remain under-investigated, especially in early disease stages. This study investigated changes in social cognition over a two-year follow-up period in individuals with early relapsing-remitting multiple scleros...

Characterization of the Healthy Ocular Mycobiome of Purebred Lusitano Horses Using Oxford Nanopore Long-Read Sequencing

The ocular surface represents a unique microbial ecosystem continuously exposed to environmental microorganisms; however, the fungal component of the healthy equine ocular microbiome remains poorly characterized. This study aimed to characterize the ocular surface mycobiome of 12...

Characterization of the simulation technician profile in Portugal: a cross-sectional study

Abstract Background Effective simulation-based education (SBE) requires specialized technical expertise to manage increasingly complex equipment. While simulation technicians are recognized as vital to high-quality programs, their roles remain poorly defined internationally and u...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Salience Network Dynamics Across Spontaneous Attacks, Interictal Rest and Interictal Pain Imagery in Menstrually Related Migraine

The persistent sensitivity to sensory and painful stimuli of people with migraine has been associated with disruption of the salience network (SN). Although migraine is characterized by severe head pain attacks, brain changes have been observed in people with migraine in between...

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...