Hospital Civil de Guadalajara

From Narrative Decisions to Assessment Evidence: A Narrative-Based Assessment Framework for Serious Games: A Pilot Feasibility Study

Assessing socially situated decision-making is challenging when assessment approaches separate observable decisions from the contexts in which they occur. This study proposes and operationalizes a seven-stage Narrative-Based Assessment (NBA) framework for eliciting and interpreti...

Divergent Organism-Specific Trajectories of Multidrug Resistance Across the COVID-19 Pandemic: An Interrupted Time-Series Study in a Mexican Tertiary Hospital, 2017–Early 2026

Background/Objectives: Whether the COVID-19 pandemic uniformly increased antimicrobial resistance (AMR) is contested, and aggregate analyses may mask organism-specific patterns. The objective of the study was to characterize changes in the level and slope of monthly multidrug-res...

Associations of Physical Activity, Sedentary Behavior, and Handgrip Strength with Clinical Characteristics in Women with Rheumatoid Arthritis from Western Mexico

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects synovial joints and leads to functional impairment. Modifiable factors such as physical activity (PA), sedentary behavior (SB), and handgrip strength (HGS) may influence clinical and functional out...

Describing Patient Characteristics, Treatment Patterns, and Disease Burden Among Patients with Alopecia Areata in Mexico: A Secondary Analysis of the Adelphi Real World Alopecia Areata Disease Specific Programme

Alopecia areata (AA) is a common autoimmune disease characterized by nonscarring hair loss, yet real-world data on AA in Mexico are sparse. This study aimed to characterize disease burden and identify unmet treatment needs among patients with AA in Mexico. Clinical data were anal...

Expanding the Clinical and Molecular Spectrum of Cartilage-Hair Hypoplasia in the Mexican Population

Cartilage-hair hypoplasia (CHH) is a rare autosomal recessive skeletal dysplasia caused by variants in RMRP (RNA component of mitochondrial RNA processing endoribonuclease), which encodes a non-coding RNA. Despite its well-established clinical and molecular spectrum in some popul...

Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.

BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort from the Global AlcHep...

Comparative Effectiveness Research in the Americas on Penetrating Brain Injury: The COMPAS-PBI Study Protocol.

BACKGROUND AND OBJECTIVES: Penetrating brain injury (PBI) is a highly lethal form of traumatic brain injury, with substantial mortality and marked differences across high-income countries and low- to middle-income countries. The aim of the Comparative Effectiveness Research in th...

LINAC-based stereotactic radiosurgery targeting the hippocampus in mesial temporal lobe epilepsy: a single-center case series

BACKGROUND: Epilepsy is a neurological disorder affecting over 50 million people worldwide, with a global incidence of 7.6 per 1,000 individuals. Mesial temporal lobe epilepsy (MTLE) is characterized by recurrent, unprovoked seizures originating in the temporal lobe. The standard...

Eosinopenia as an Independent Predictor of Complicated Acute Appendicitis: Usefulness in Adults, Not in Children

Background. The role of eosinophils in acute appendicitis (AA) is not well known. The aim of this study is to analyze whether peripheral blood eosinophil concentration can be useful in predicting episodes of complicated AA among pediatric and adult populations.Methods. A retrospe...