Hôpitaux Universitaires de Strasbourg

Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort

Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial - driven by disease progression, treatment tox...

Prognostic performance of the systemic immune-inflammation index in hospitalized patients with COVID-19: a multicenter emergency department study

Abstract Introduction The systemic immune-inflammation index (SII) has been proposed as a simple prognostic biomarker in COVID-19, but its performance relative to routinely available inflammatory markers and its incremental value beyond clinical predictors remain uncertain. We ev...

Sensitive reverse transcription-digital droplet PCR-based discrimination of hepatitis delta virus RNAs reveals differential effects of interferon-α on viral RNA species

Hepatitis delta virus (HDV) replication relies on the production of distinct viral RNA species, including genomic (HDV-G), antigenomic (HDV-AG) and mRNAs (HDV mRNAs), which differ in abundance and function. However, the lack of sensitive and quantitative approaches allowing their...

Specific plasmid profiles of Clostridium butyricum associated with grouped cases of necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is an unpredictable condition that is commonly encountered in neonatal intensive care units. NEC considered one of the most severe gastrointestinal diseases affecting preterm infants and is often fatal. In this study, we performed a genomic analysi...

Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study

Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (...

Relationships between general practice residents’ level of reflection and their competencies development: results from a pilot cross-sectional study

Reflective practice is a cornerstone for developing professional competence. Despite its importance, the relationship between levels of reflection and competence remains underexplored in medical education. This association was described in trainee teachers. Along with initiating...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...