Hôpital Paul-Brousse

A Contemporary Review of Resectability and Treatment Strategies for Colorectal Liver Metastases: Part 1—Diagnosis, Defining Resectability, and Management of Upfront Resectable and Synchronous Disease

Background/Objectives: Colorectal liver metastases (CRLMs) remain a major determinant of long-term outcome. Although hepatic resection offers the best chance of durable survival, the definition of resectability has evolved beyond technical feasibility alone. This review aims to p...

Mental health benefits of social prescribing in the general population and among people with mental disorders: an umbrella review

Social prescribing (SP) aims to connect patients to non-medical community resources to address social determinants of health. Here, we aimed to review the evidence of SP’s effects for mental health in the general population and among patients with mental disorders. We conducted a...

Association of cryptic pregnancy and alcohol consumption with fetal alcohol spectrum disorder: a nationwide population-based study of 5 million women in 2015–2022

Cryptic pregnancy (CP) also known as pregnancy denial remains an underexplored risk factor for FASD. To our knowledge, there is no available epidemiologic data in the scientific literature exploring the association between CP and FASD. This study aimed to examine the association...

Limitations of routine hepatitis E virus diagnosis in Central African Republic: a comparative evaluation of serological and molecular assays

In the Central African Republic (CAR), data on the disease burden of hepatitis E virus (HEV) infection are limited despite recurrent epidemics. HEV is not routinely tested for in cases of elevated transaminases. Our objective was to evaluate the sensitivity and the specificity of...

Alcohol and tobacco in cancer: A unified framework of interaction across carcinogenic pathways and cancer types

Background Alcohol and tobacco are among the leading preventable causes of cancer worldwide and frequently co-occur. While both are well-established independent carcinogens, their combined effects remain insufficiently characterized and inconsistently interpreted across cancer ty...