Hôpital Nord

Prognostic performance of the systemic immune-inflammation index in hospitalized patients with COVID-19: a multicenter emergency department study

Abstract Introduction The systemic immune-inflammation index (SII) has been proposed as a simple prognostic biomarker in COVID-19, but its performance relative to routinely available inflammatory markers and its incremental value beyond clinical predictors remain uncertain. We ev...

Management of hemodynamically stable penetrating chest trauma without cardiac injury in Marseille

Abstract Background Penetrating chest trauma (PCT) is uncommon in Western Europe but carries substantial morbidity. Non-operative treatment (NOT) is widely practiced in regions with high rates of penetrating injuries, whereas European centers continue to report higher surgical ex...

Subcutaneous isatuximab by on-body-injector plus bortezomib, lenalidomide, and dexamethasone in newly diagnosed transplant-ineligible multiple myeloma: ISASOCUT study

Isatuximab–bortezomib–lenalidomide–dexamethasone (Isa-VRd) has emerged as a standard of care for newly diagnosed multiple myeloma transplant-ineligible patients. A subcutaneous (SC) formulation of isatuximab delivered via an on-body injector (OBI) has been developed to facilitate...

Transdiaphragmatic rupture of a calcified hepatic hydatid cyst into the bronchial tree: CT findings of a bronchobiliary fistula

Transdiaphragmatic rupture of hepatic hydatid cysts into the bronchial tree is a rare but severe complication that may mimic pulmonary infection. We report the case of a 61-year-old man who presented with fever, dyspnea, and right thoracic pain, with initial CT findings suggestiv...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Specific plasmid profiles of Clostridium butyricum associated with grouped cases of necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is an unpredictable condition that is commonly encountered in neonatal intensive care units. NEC considered one of the most severe gastrointestinal diseases affecting preterm infants and is often fatal. In this study, we performed a genomic analysi...

Evaluation of the Cardiac Autonomic Control of Patients with Arterial Hypertension

Background: Hypertension remains the most prevalent risk factor for cardiovascular diseases (CVD). Scientific literature had found a dysregulation of heart by autonomic nervous system in hypertensive patients. Objective: Our objective was to evaluate the autonomic nervous control...

Matrix‐Activated Aptamer Sensors for Human Serum Analysis

ABSTRACT Owing to their ease of operation, solution‐phase fluorescent sensors hold a crucial position among aptamer‐based detection tools. However, their performance is regularly compromised when exposed to increasing levels of blood fluids, such as human serum, which limits thei...

Matrix‐Activated Aptamer Sensors for Human Serum Analysis

ABSTRACT Owing to their ease of operation, solution‐phase fluorescent sensors hold a crucial position among aptamer‐based detection tools. However, their performance is regularly compromised when exposed to increasing levels of blood fluids, such as human serum, which limits thei...

Real-World Use of Adjuvant Nivolumab for Resected Stage III–IV Melanoma: 2-Year Analysis of AdjuMel

Following the positive findings of the phase 3 CheckMate 238 trial, adjuvant nivolumab has become a standard therapy in patients with completely resected stage III–IV melanoma. The prospective, ongoing AdjuMel study is evaluating the real-world use, effectiveness, and safety of a...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Demoting the Master Control Program: Deterministic Orchestration of a Fleet of LLM Agents

Multi-agent systems that build software usually coordinate their agents through a language model: an orchestrator reasons in prose about who works next, whether a task is done, and when to involve the human operator. That puts a probabilistic component on the control path of a sy...

From thunder to silence: Cochlear implantation for bilateral profound sensorineural hearing loss after lightning strike

INTRODUCTION: Lightning strikes can cause diverse neuro-otologic injuries. Tympanic membrane rupture is common, whereas bilateral profound sensorineural hearing loss with vestibular dysfunction and perilymphatic fistula is rare. Cochlear implantation for lightning-induced deafnes...