Hôpital Fernand-Widal

Increased CSF PKR activation in Alzheimer’s disease is associated with APOE4 genotype

Abstract Objective Protein kinase R (PKR) is a stress-activated kinase implicated in translational control, neuroinflammation, and neurodegeneration. Although increased PKR activation was reported in Alzheimer’s disease (AD), prior studies relied on semi-quantitative methods. Thi...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...