Hôpital Avicenne

Fibronectin-Assisted Coating of Low-Molecular-Weight Fucoidan Creates a Biomimetic Interface for Endothelialization of Cobalt-Chromium Stents

Incomplete or delayed endothelialization after stent implantation compromises vascular healing and increases the risk of restenosis and late thrombosis. To address this limitation, Cobalt-Chromium (Co-Cr) stents were modified with a biomimetic coating combining Low-Molecular-Weig...

Extracorporeal cardiopulmonary resuscitation strategies for refractory out-of-hospital cardiac arrest

Abstract Background Refractory out-of-hospital cardiac arrest (OHCA) is almost invariably fatal. Extracorporeal cardiopulmonary resuscitation (ECPR) has emerged as a feasible rescue treatment and may improve outcomes in highly selected patients. On-scene and hospital-based ECPR e...

Integrated Droplet Microfluidic Platform for Single-Spheroid Photothermal Nanotherapy and Morphology-Driven Response Prediction

Abstract Photothermal therapy (PTT) is a promising cancer treatment modality, but its evaluation remains limited by the lack of physiologically relevant and quantitatively controlled in vitro platforms. Here, we present a droplet-based microfluidic platform that enables single-sp...

Bronchial artery hypertrophy: a novel vascular manifestation of telomere biology disorders in pulmonary fibrosis

Fibrosing interstitial lung diseases (ILD) associated with telomere-related gene (TRG) mutations exhibit extra-thoracic features suggesting systemic angiogenesis abnormalities. We investigated the bronchial arterial circulation in TRG-mutated ILD patients. We measured right and l...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Rule‐Based Versus Generative Extraction of Psychological Symptoms From Forensic Medical Certificates: A Feasibility Study in the French ORFeAD Network

ABSTRACT Forensic medical certificates for victims of interpersonal violence describe psychological symptoms in unstructured prose, rarely explicit and requiring inference. To assess the feasibility of two extraction pipelines—rule‐based and a locally served generative large lang...

Relapsed/refractory WAldenström macroglobulinemia patients treated by VEnetoclax with or without anti-CD20 antibody: WAVE a retrospective study of the French CLL/WM group (FILO)

Abstract Recently venetoclax (Ven) monotherapy showed promising efficacy for relapsed/refractory (R/R) Waldenström macroglobulinemia (WM), a population with significant medical unmet need. We report the efficacy and safety of Ven associated or not with anti-CD20 therapy, in a rea...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Antifibrotic therapy in patients with pleuroparenchymal fibroelastosis: a multicentric observational study

Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease characterized by upper-lobe predominant pleural and subpleural fibrosis and associated with poor prognosis. No evidence-based medical therapy is currently established, and lung transplantation remains the...