HOPE Clinic

Diabetic Peripheral Neuropathy: Implementing Guidelines into Practice

Diabetic Peripheral Neuropathy (DPN) is a common and debilitating complication of diabetes, affecting up to 50% of patients. Early identification and management of DPN are crucial to minimize complications and maintain patient quality of life. Multiple guidelines have been develo...

Systemic and Mucosal Antibody Responses Against Neisseria gonorrhoeae (Ng) Outer Membrane Vesicle Antigens following Four-Component Meningococcal Serogroup B (4CMenB) Immunization in Healthy Adults: A Randomized Phase II Trial

Meningococcal serogroup B (MenB) vaccines containing outer membrane vesicles (OMVs) may provide cross-protection against Neisseria gonorrhoeae infections but vaccine-induced mucosal immune responses remain poorly characterized. This phase 2, double-blind, randomized, placebo-cont...

Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses

The emergence of the SARS-CoV-2 Omicron BA.2.86 subvariant, a lineage derived from the BA.2 strain, led to the 2024-2025 COVID-19 vaccine update to include KP.2 or related JN.1-lineage spike antigens. We evaluated the magnitude, breadth, and durability of humoral immune responses...

Pharmacokinetic and pharmacodynamic sub-study of trans-arterial vs. intravenous gemcitabine in the TIGeR-PaC phase 3 clinical trial

Abstract Purpose Localized intra-arterial delivery of gemcitabine (IAG) may provide advantages in terms of increased tissue concentration and decreased systemic dosing. We hypothesized IAG may result in decreased systemic gemcitabine concentration and associated side effects due...