Holy Cross University

Depressive Symptoms in Adults with Obesity and Their Associations with Sociodemographic, Health and Lifestyle Factors: A Secondary Analysis of a Cross-Sectional Study

Background/Objectives: Research indicates a bidirectional association between obesity and depression. The co-occurrence of both disorders has serious clinical implications. The aim of this study was to assess the prevalence of self-reported depressive symptoms (DS) in a group of...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Nipple-Areola Complex Reinnervation Using Intercostal Nerve Grafts in Implant-Based Reconstruction.

Despite successful aesthetic outcomes, immediate breast reconstruction is frequently accompanied by significant sensory loss, compromising patient quality of life. While neurotization techniques are established for autologous flaps, a standardized solution for implant-based recon...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

Mammography-Based Radiomics for Prediction of Nodal Status and Disease Burden in Breast Cancer: A Temporally Validated Study

Objectives: We evaluated the performance of mammography-based radiomics in prediction of clinical nodal status, clinical tumor stage, clinical disease stage, status of the PIK3CA mutation and concordance with the radiologist-assessed BI-RADS category. Mammography is often the fir...