Hokkaido University Hospital

TFEB drives ER stress-induced apoptosis and limits cyst growth in polycystic kidney disease

Abstract Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts and loss of renal function. Here, it was demonstrated that transcription factor EB (TFEB) activation in cyst-lining epithelial cells enhances their susceptibili...

Comparison of Nationwide Volumes for Five Major Gastrointestinal Surgical Procedures in Japan: Implications From Publicly Available NCD and NDB Open Data

ABSTRACT Aim In Japan, the National Clinical Database (NCD), a clinician‐reported registry, and the National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data (NDB Open Data), an administrative claims database, are both widely used as nationwide...

Effect modification by baseline lactate in the association between time to assigned mean arterial pressure target and outcomes in older patients with septic shock: a post hoc analysis of the OPTPRESS trial

Time to target mean arterial pressure (TTT-MAP) may capture the temporal dimension of circulatory recovery in septic shock; however, its prognostic relevance needs clarification. This study aimed to investigate the impact of baseline lactate on the TTT-MAP-clinical outcome associ...

Early administration of calcineurin inhibitors limits tolerogenic effect of PTCy in allogeneic hematopoietic transplant

We recently demonstrated early administration of calcineurin inhibitors (CNIs) after murine allogeneic hematopoietic cell transplantation (allo-HCT) inhibits terminal exhaustion of donor T cells and hampers tolerance induction. However, the role of CNIs in regulating T-cell exhau...

Comparative in vivo evaluation of colistin resistance determinants in Escherichia coli clone ST131

Background Colistin is a last-resort antimicrobial for multidrug-resistant (MDR) Gram-negative infections. Health risks associated with colistin resistance are commonly inferred from resistance phenotypes, despite limited in vivo evidence linking resistance determinants to pathog...

Suspected Small Bowel Bleeding

GOALS: We identified prognostic factors for mortality after Suspected small bowel bleeding (SSBB) and evaluated the impact of severe anemia and other clinical factors on patient survival. BACKGROUND: SSBB is characterized by an inability to identify the cause of bleeding despite...