Hokkaido Pharmaceutical University

High tryptophan 2,3-dioxygenase expression promotes lenvatinib resistance in hepatocellular carcinoma

Background Lenvatinib (LEN) is a key first-line therapy for advanced hepatocellular carcinoma (HCC), but intrinsic and acquired resistance limits its long-term efficacy. We aimed to identify novel mechanisms underlying LEN resistance and to explore clinically relevant biomarkers...

A bibliometric-systematic review of CGM’s application in lifestyle and behavioral research among healthy individuals: proposing a novel typology

Abstract Background Blood glucose management has progressed from diabetes treatment to tracking trends in healthy populations since the introduction of continuous glucose monitoring (CGM) in 1999. Previously, this population was difficult to study using traditional self-monitorin...