Hochschule Aalen

Comprehensive Online Two-Dimensional nanoLCxCZE-MS for Deep Top-Down Proteomics

Abstract Understanding proteoforms, i.e., the various molecular forms in which proteins can exist, is important for deciphering biological processes and diseases. While capillary zone electrophoresis (CZE) proved advantageous for proteoform separation, limited sample loading capa...

Detecting Anomalous Cell Behavior in Electrochemical Battery Testing Using Machine Learning

The growing availability of structured battery databases opens new opportunities for data‐driven quality control in battery manufacturing. Efficient identification of anomalous cells is critical for ensuring safety, performance, and longevity. In this work, we present a machine‐l...

Supporting AI Readiness Through Digital Workflows in Materials Science

Materials science produces heterogeneous data across experiments, simulations, and industrial processes that often remain bound to local formats, manual procedures, and project‐specific software. Digital workflows address this fragmentation through explicit, repeatable, and machi...

Modulating proteoform charge states and signal intensities in LC-MS using a nanoflow sheath liquid interface

To investigate intact proteins in biological samples, hyphenation of mass spectrometers (MS) with separation techniques like liquid chromatography (LC) or capillary zone electrophoresis (CZE) is crucial. While reversed-phase nanoLC is typically coupled directly (“sheathless”) to...

Spatial Eigenanalysis of 2D Deformation Energies

Abstract We present the first closed‐form, per‐element eigensystems for 2D deformation energies in the primary domain of spatial coordinates. Previous analyses have only been able to find such eigensystems in proxy coordinates such as the deformation gradient, but as the spatial...

Impact of oxygen and hydrogen traces on the focused ion beam sputter rate and secondary ion mass spectrometry intensity detection of graphite

Trace amounts of oxygen and hydrogen can strongly influence the formation of negative carbon ions during focused ion beam–secondary ion mass spectrometry (SIMS) analysis of graphite. In this study, the sputtering behavior of graphite and the detection of single and clustered carb...