Hiroshima University Hospital

Generational Differences in Illness‐Related Uncertainty Among Haemophilia Carriers: A Qualitative Study Using Mishel's Uncertainty in Illness Theory

AIM: Haemophilia carriers (HCs) have historically been regarded as asymptomatic or only mildly affected, resulting in under-recognition of bleeding symptoms and unmet healthcare needs. Although advances in healthcare and access to information have changed the experience of haemop...

Comprehensive gait characteristics on electromagnetic stance-control knee ankle foot orthosis in healthy individuals

Abstract Computer-controlled knee ankle foot orthosis (KAFO) has the potential to contribute to gait training and functional walking assistance by ensuring knee stability during stance while allowing knee flexion during swing; however, evidence regarding the gait characteristics...

Uncontrolled manifold analysis of center-of-mass control during gait before and after total hip arthroplasty in patients with hip osteoarthritis: a secondary analysis of a prospective cohort study

Abstract Background Total hip arthroplasty (THA) is an effective treatment for hip osteoarthritis (HOA), and postoperative gait analysis is important for evaluating recovery and designing rehabilitation strategies. However, conventional gait assessment has focused primarily on th...

An Improved Rat Model of Myocardial Infarction Without Invasive Intubation

Background/Aim: The standard surgical procedure for inducing myocardial infarction (MI) in rat models via left anterior descending (LAD) coronary artery ligation typically requires invasive endotracheal intubation. While recent techniques have avoided intubation, they necessitate...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

Mechanistic insights into the immunomodulatory and antibacterial activity of the Japanese Kampo Formula Hainosankyuto

Purpose This study aimed to quantify the in vitro antibacterial activity of the Japanese herbal formula Hainosankyuto (HNST) against Gram-positive and Gram-negative bacteria and to elucidate its immunomodulatory effects on human monocytes. Methods The antibacterial activity of HN...

Algorithm for classifying the underlying pathologies in postpartum hemorrhage using bleeding rate, fibrinogen, and fibrin/fibrinogen degradation products: a case series study

Abstract Background Understanding patients’ underlying pathologies is essential for appropriate treatment during postpartum hemorrhage (PPH) management. The objective of this study is to develop an algorithm that quantitatively classifies the underlying pathologies in PPH using c...

Association of COVID-19 infection with welfare recipients in Japan: a retrospective cohort study

Abstract Background The COVID-19 pandemic has exacerbated poverty among vulnerable populations worldwide. However, no study has clarified the extent to which COVID-19 infection increases the likelihood of becoming a welfare recipient in Japan. Therefore, we examined the associati...