Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Adverse impact of deletion of the chromosome 6 on clinical outcomes after allogeneic hematopoietic transplantation

Graft-versus-leukemia (GVL) effect is mainly mediated by alloreactive T and NK cells through human leukocyte antigen (HLA). Although most HLA genes are located on the short arm of chromosome 6, the clinical significance of deletion of the short arm of chromosome 6 (del6p) which c...