Hiroshima City Asa Citizens Hospital

Treatment Outcomes for Gastric Cancer With Positive Peritoneal Lavage Cytology or Localized Peritoneal Metastasis

Importance In the era of modern systemic chemotherapy, the optimal treatment strategy for gastric cancer with positive peritoneal lavage cytology (CY1) and/or localized peritoneal metastasis (P1a) remains controversial. Objective To explore the optimal treatment strategy for pati...

Risk factors for recurrence after neoadjuvant docetaxel+cisplatin+5-fluorouracil (DCF) followed by surgery for esophageal squamous cell carcinoma: a single-institution retrospective analysis

The JCOG1109 trial proved the superiority of neoadjuvant chemotherapy (NAC) with docetaxel, cisplatin, and 5-fluorouracil (DCF) to chemotherapy with cisplatin and 5-fluorouracil (CF). Concurrently, advances in immune checkpoint inhibitors (ICIs) have introduced new perioperative...

Patient-derived organoids for modeling therapy tolerance, persistence, and resistance in cancer

Therapy resistance remains a major obstacle to durable cancer control. Across cytotoxic chemotherapy, molecularly targeted therapy, immunotherapy, endocrine therapy, and cellular therapy, treatment failure may manifest as primary nonresponse, residual disease, reversible regrowth...

Abdominal aortic calcification predicts anastomotic leakage after gastrectomy: a multicenter retrospective cohort study from the Hiroshima Surgical study group of Clinical Oncology

Anastomotic leakage (AL) is a critical complication following gastrectomy for gastric cancer (GC). Abdominal aortic calcification (AAC), a surrogate marker of systemic atherosclerosis and frailty, has been associated with AL only in single-center studies. This multicenter study e...