Hirosaki University

Delayed and multisystem immune-related adverse events in MSI-high colon cancer treated with nivolumab plus ipilimumab

Abstract Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) involving multiple organs. However, delayed-onset, multisystem irAEs after treatment discontinuation are uncommon. Here, we present a rare case of a man in his 50s with microsatellite ins...

SensorW: Open-Source Wear Operating System Platform for Continuous Global Positioning System and Multimodal Sensor Data Collection in Real-World Settings

Digital phenotyping requires continuous, real-world collection of multimodal behavioral and physiological data. Although several smartphone-based sensing frameworks have been developed and used, open-source platforms for long-term smartwatch sensor data acquisition remain limited...

Impact of adjuvant chemotherapy on renal impairment patients following radical nephroureterectomy in upper tract urothelial carcinoma: a multicenter retrospective study

Abstract To evaluate the impact of adjuvant platinum-based chemotherapy (AC) on oncological outcomes in high-risk upper tract urothelial carcinoma (UTUC) patients with postoperative renal impairment following radical nephroureterectomy (RNU). Among 1050 patients who underwent RNU...

The Pacific seaweed pipefish Syngnathus schlegeli exhibits exceptionally high levels of polygynandry among fishes with paternal egg care

Abstract Syngnathid fishes (family Syngnathidae), characterised by male pregnancy via a brood pouch, provide an exceptional model system for studying the relationship between mating systems and sexual selection, as they display extraordinary diversity in both mating systems and s...

Mechanism of the influence of solids holdup on the heat transfer rate of high-density particle flows in cyclone pyrolyzer

Introducing centrifugal force into a free-fall downer (FFD) creates a cyclone pyrolyzer (CP), which can achieve a synergistic effect of high gas velocity and localized high solids holdup (>0.1) to enhance heat transfer in high-density particle flows. However, the mechanism of int...

Shall we score? The SHALL-WE score for optimizing sclerotherapy in superficial lymphatic malformations

No standardized tool guides the decision of when to escalate beyond sclerotherapy in lymphatic malformations (LMs). We developed the SHALL-WE score (Severity, Histology, And Location—Lymphatic malformation: When to Escalate) to define the optimal sclerotherapy threshold in superf...

Persistent Cross-Institutional Domain Shift in Narrow-Band Imaging Classification of Colorectal Lesions and the Utility of Site-Specific Fine-Tuning

Background/Objectives: Cross-institutional transfer of endoscopic deep learning models may be limited by acquisition and preprocessing differences. We reassessed persistent domain shift after correcting Facility B input linkage and validation design. Methods: A preflight audit co...

Prognosis and risk factors by histologic type of malignant ovarian germ cell tumors in Japan: a JSOG gynecologic tumor registry-based study

Objective: This study evaluated prognosis and risk factors for overall survival (OS) in malignant ovarian germ cell tumors (MOGCTs) using data from the Japan Society of Obstetrics and Gynecology tumor registry.Methods: Data from 1,538 MOGCT patients (2004MOGCT patients ( -2019) )...

Charge-Neutral N–H···Br as a Hydrogen-Bond Family for the Construction of Hydrogen-Bonded Organic Frameworks

Abstract The design, synthesis, and application of porous molecular crystals constructed using intermolecular hydrogen bonds (hydrogen-bonded organic frameworks; HOFs) have attracted significant attention due to the potential flexibility and solution processability of HOFs, which...

First formal record of the feeding habits of Saileriolidae (Hemiptera, Heteroptera, Pentatomomorpha, Pentatomoidea), with redescription of Bannacoris hyalinus (Schaefer & Ashlock, 1970), comb. nov. endemic to Vietnam

This dataset contains the digitized treatments in Plazi based on the original journal article Souma, Jun, Le, Cuong Viet Canh, Pham, Thai-Hong (2024): First formal record of the feeding habits of Saileriolidae (Hemiptera, Heteroptera, Pentatomomorpha, Pentatomoidea), with redescr...

Alpha track counting on CR-39 detectors using YOLOv8s: Model development and application

Precise counting and detection of alpha tracks on CR-39 detectors is a critical part of measuring indoor radon and thoron. Traditional software, such as ImageJ, often struggles with background artifacts and overlapping tracks. In this work, we developed a deep learning-based meth...

Longitudinal hemifield-specific macular ganglion cell complex thinning and its association with arterial stiffness in eyes without baseline glaucomatous abnormalities

PURPOSE: To characterize longitudinal hemifield-specific changes in macular ganglion cell complex (GCC) thickness in eyes without baseline glaucomatous abnormalities and to evaluate whether arterial stiffness, assessed by brachial-ankle pulse wave velocity (baPWV), is associated...

Structure-oriented deep learning for semantic segmentation of bridge point clouds

Bridges built during the post-war construction boom are reaching the end of their design life, and their inspection still relies mainly on manual visual assessment. The specific question addressed is whether bridge components can be segmented accurately and efficiently from raw p...

Association between central sensitization symptoms and cold hypersensitivity severity in older adults: a cross-sectional analysis from the Otassha Study

Abstract Introduction: Cold hypersensitivity (Hie) is a common complaint among older adults in East Asia and has traditionally been attributed to peripheral circulatory dysfunction. However, emerging evidence suggests that central sensitization (CS) may also contribute. This stud...

Baseline airway dysfunction and small-airway abnormality burden are longitudinally associated with adverse ultradistal radial bone density outcomes in a 5-year cohort

Impaired pulmonary function has been linked to lower bone mineral density and higher fracture risk, but longitudinal evidence on airway dysfunction and subsequent peripheral bone-density outcomes remains limited. We investigated whether baseline airway dysfunction, FEV1/FVC, and...

Variational autoencoders can detect coronary artery disease in myocardial perfusion SPECT images

Abstract Purpose Variational autoencoders (VAEs) can detect unsupervised anomalies in medical images. We aimed to determine whether a VAE could automatically detect anomalies in myocardial perfusion SPECT (MPS) images. We then interpreted the training and generative processes of...

Phase transition in a long-memory log-Gaussian Cox process

We study a stochastic point process with power-law temporal correlations driven by hidden variables. We show that a generalized Merton type model under an exponential-tail asset assumption—obtained by replacing the Gaussian cumulative distribution function with a logistic CDF— to...

Performance and Economic Boundary Analysis of an Integrated PV–Solar-Thermal–Battery–Hydrogen System for a Cold-Climate Dwelling: A Case Study in Northern Japan

Cold-climate dwellings can face coincident electricity and domestic hot-water shortfalls in winter, when solar availability is at its lowest. This study evaluates an integrated residential system for Aomori, Japan, combining photovoltaics, evacuated-tube solar water heating, and...

Moderate aortic stenosis identified during intensive care admission for a non-cardiac primary diagnosis and 90-day mortality: a retrospective cohort study using the MIMIC-IV echocardiography database

Abstract Background Moderate aortic stenosis is associated with reduced survival in ambulatory cardiology populations, but its prognostic significance when identified during an intensive care admission for a non-cardiac primary diagnosis is unknown. We examined its association wi...

Sarcopenia affects the outcomes and tolerability in patients with interstitial lung disease receiving nintedanib: a retrospective study

Nintedanib is approved for various interstitial lung diseases (ILDs). Although sarcopenia, which is characterized by a loss of skeletal muscle mass, is known to affect the outcome of ILD, the outcome of patients with sarcopenia receiving nintedanib remains unclear. Fifty-six pati...