Hindu College of Pharmacy

White analytical chemistry-driven, blue-guided LC-MS/MS method for simultaneous quantification of metformin and sitagliptin in human plasma

Abstract A liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of metformin (MET) and sitagliptin (SIT) in human plasma. Chromatographic separation was achieved on an Endurus C18 pro-XR 4.6 × 100 mm column, using methanol and 2 m...

Renal cell carcinoma: Molecular mechanisms and emerging therapeutic strategies

Renal cell carcinoma (RCC) poses a persistent clinical challenge, mainly due to its resistance to conventional therapies. With increased detection through modern imaging, more cases are being identified early, yet advanced or metastatic RCC remains challenging to treat. A deeper...

Integrative Bioinformatics Identification of Baicalein as a Phytochemical Inhibitor of CHEK1 in Serous Ovarian Cancer: A Multi-Stage In Silico Drug Discovery Approach

Background: Serous ovarian cancer (SOC) is the most aggressive subtype of epithelial ovarian cancer, frequently diagnosed at advanced stages with poor prognosis and chemotherapy resistance. Checkpoint kinase 1 (CHEK1), a key regulator of the DNA damage response, is overexpressed...