Hindu College of Pharmacy

Impact of Adversarial Attacks on Robust Cancer Detection in Medical Images using Improved Optimization-based Adaptive Multi-Scale ShuffleNetV2

The uncontrolled proliferation of abnormal cells within any region of the body is called cancer. A collection of disorders brought on by aberrant cell growth in various sections of the body is together referred to as cancer. More than one hundred forms of cancer exist, including...

Mechanistic understanding and comprehensive insights into green-synthesized cerium oxide nanoparticles and its applications

Green synthesis offers a sustainable and biocompatible alternative to conventional chemical methods for Cerium oxide nanoparticle (CNPs) synthesis. It minimizes toxic waste and environmental hazards while improving functional performance. Chemical routes often require high temper...

MXene-based biosensors for hospital-on-chip diagnostics: a coordination chemistry framework from materials design to clinical translation

MXenes, a rapidly expanding family of two-dimensional transition metal carbides and nitrides, have emerged as promising materials for hospital-on-chip (HoC) diagnostics because of their high electrical conductivity, chemically tunable surfaces, and versatile biofunctionalization....

Empagliflozin alleviates STZ-induced diabetic neuropathy, anxiety and depression-like behavior in C57/BL-6 mice

Background Diabetes mellitus (DM) is frequently associated with neuropathic complications and concurrent neuropsychiatric manifestations, including anxiety and depression-like behaviors. Together these complications add on to disease burden, impair quality of life and need indivi...

Efficient One Pot Synthesis of 3-Methyl-4-(Hetero) Arylmethylene Isoxazole-5(4H)-Ones Derivatives Catalyzed by [EMIm][BH3CN] Ionic Liquid Under Reflux and Microwave Conditions

AbstractHere, we have developed an expeditious and efficient protocol for the synthesis of isoxazol-5(4H)-onederivatives catalysed by the ionic liquid [EMIm][BH3CN] using ethanol as a solvent under microwaveirradiation (MW, 240 W, 4–6 min) and conventional reflux conditions. The...

A Review on Advancing Stem Cell Therapy and Tissue Engineering to Regenerate Damaged Tissues and Organs

In the field of regenerative medicine, developing stem cell therapy and tissue engineering has become a game-changing strategy that holds promise for replacing and repairing damaged organs and tissues. Innovative biological interventions are required since traditional therapy app...

White analytical chemistry-driven, blue-guided LC-MS/MS method for simultaneous quantification of metformin and sitagliptin in human plasma

Abstract A liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of metformin (MET) and sitagliptin (SIT) in human plasma. Chromatographic separation was achieved on an Endurus C18 pro-XR 4.6 × 100 mm column, using methanol and 2 m...

Renal cell carcinoma: Molecular mechanisms and emerging therapeutic strategies

Renal cell carcinoma (RCC) poses a persistent clinical challenge, mainly due to its resistance to conventional therapies. With increased detection through modern imaging, more cases are being identified early, yet advanced or metastatic RCC remains challenging to treat. A deeper...

Integrative Bioinformatics Identification of Baicalein as a Phytochemical Inhibitor of CHEK1 in Serous Ovarian Cancer: A Multi-Stage In Silico Drug Discovery Approach

Background: Serous ovarian cancer (SOC) is the most aggressive subtype of epithelial ovarian cancer, frequently diagnosed at advanced stages with poor prognosis and chemotherapy resistance. Checkpoint kinase 1 (CHEK1), a key regulator of the DNA damage response, is overexpressed...