Henry M. Jackson Foundation

Serological and transcriptomic response of African fruit bats to immune challenge with recombinant vaccines expressing Ebola or Nipah virus antigens

Abstract Bats are hosts to diverse zoonotic viruses which can cause high case fatality rates in humans. Since detecting viruses in bats is difficult, antibodies are often used for surveillance, though their significance remains unclear in the absence of in vivo immunological stud...

Newly Diagnosed Anxiety, Mood, and Trauma-Related Disorders Following COVID-19 Infection Among U.S. Military Beneficiaries

The long-term neuropsychiatric effects of COVID-19 are still unclear. Various mental health conditions are known to be influenced by biopsychosocial factors. We sought to investigate whether COVID-19 infection increases the risk for newly diagnosed anxiety, mood, or trauma and st...

Brain Penetrant Calcium Channel Blockers Were Not Associated With Reduced Alcohol Consumption: Converging Results From Two Large Independent Cohort Studies Using Electronic Health Records

ABSTRACT Purpose Alcohol use disorder (AUD) remains a major public health problem, with few effective treatments. L‐type calcium channel blockers (LTCCBs) have genetic and preclinical support as potential treatments for AUD. Methods We evaluated whether brain penetrant (BP)‐LTCCB...

Histology resolved proteomic characterization of the triple negative breast cancer tumor immune microenvironment

Treatment options for the highly aggressive triple-negative breast cancer (TNBC) subtype remain limited, though the immune microenvironment represents a promising therapeutic target. We conducted a histology resolved tumor microenvironment analysis of TNBC by employing deep quant...

COVID-19 and Appendicitis: Insights from a Retrospective Study

To identify whether a relationship exists between COVID-19 and appendicitis and compare the incidence of appendicitis during three pandemic years to the year prior to the pandemic, we conducted two observational retrospective studies: a propensity score-matched (PSM) cohort and a...

Military Sexual Trauma and Eating Disorders: A Systematic Review and Meta-Analysis

Military sexual trauma (MST) poses a significant public health concern within military populations, with enduring health consequences including the development of eating disorders (EDs). This review synthesizes existing literature to explore the association between MST and EDs am...

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

Patients with high-risk endometrial carcinoma (HR-EC) experience substantial mortality despite multimodality therapy, molecular classification and contemporary care. We determined whether proteomic tumor programs capture lethal risk beyond established clinical and genomic classif...

Measurement of binding antibodies to SARS-CoV-2 variants elicited by natural infection and COVID-19 vaccines in a sub-Saharan African population

Abstract Data on immune responses to COVID-19 vaccination in West and Central Africa remain limited, particularly with respect to antibody (Ab) binding across SARS-CoV-2 variants and for different types of vaccine platforms. We assessed anti-spike (anti-S) antibody binding to nin...

Serum microRNA Analysis of Nonhuman Primates Prophylaxed with Gamma-tocotrienol and Exposed to Total- or Partial-body Radiation

Ionizing radiation exposure is a rising military and national security risk. Exposure to a high dose can lead to an illness called acute radiation syndrome (ARS), which poses clinical challenges. There is no Food and Drug Administration (FDA)-approved agent that can be used prior...

Crimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadth

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne, negative-strand RNA virus that causes outbreaks of lethal hemorrhagic fever. No approved vaccines or specific antiviral treatments are available. CCHFV glycoprotein GP38 is an integral component of the pre-fusion glyc...

Natural Killer Cell Phenotypic Changes and Activating Receptor Loss Posttrauma

BACKGROUND: Trauma induces significant physiological changes that can lead to substantial morbidity and mortality. Many of these changes alter immune homeostasis, which underlies seemingly disparate syndromes of systemic inflammation and global immune suppression, the causes of w...

Firearm carrying practices and motivations: A mixed methods study among adults and youth

Abstract The purpose of this participatory action, mixed methods research study was to identify motivations related to firearm carrying from a qualitative perspective, and then to use quantitative research to characterize the patterns of motivations around carrying. Qualitative i...