Henry Ford Health

Decreased function of fatty acid desaturase 1 is associated with placental foetal vascular malperfusion and highlights the key role of the maternal–foetal interface

Background Placental foetal vascular malperfusion (PFVM) is a chronic disorder characterised by impaired blood flow and abnormal vascular development, inducing adverse neonatal outcomes. Long chain polyunsaturated fatty acids (LC-PUFAs) play a crucial role in placenta health. We...

A Blueprint for Developing a Concentration in Ambulatory Care Within the PharmD Curriculum

ABSTRACT The US healthcare system is grappling with significant challenges, notably a shortage of primary care providers. Ambulatory care pharmacists are increasingly recognized as vital contributors to addressing these challenges. The Accreditation Council for Pharmacy Education...

Predicting Self-Harm Events After Emergency Department Visits Associated With Mental or Substance Use Disorder Diagnoses

OBJECTIVE: Using a machine learning model, the authors aimed to predict self-harm events within 90 days of an emergency department (ED) visit associated with a mental or substance use disorder diagnosis. METHODS: Electronic health record and claims data of patients ages ≥11 years...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Patient Perspectives on Offers of Buprenorphine in the Emergency Department

Importance Buprenorphine reduces mortality in opioid use disorder (OUD), and emergency department–initiated buprenorphine (EDIB) doubles 30-day treatment retention, yet many patients decline EDIB when offered. Patient-driven factors limiting uptake are not well characterized. Obj...

Trends in annual medication possession in older adults with type 2 diabetes

BACKGROUND: Older adults (≥65 years) make up a substantial portion of individuals with type 2 diabetes (T2D) and frequently experience multimorbidity requiring complex, costly medication regimens. Cost-related nonadherence is prevalent in this population because of fixed incomes,...

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study

Abstract Early cancer detection improves survival; however, most cancer types do not have guideline-recommended screening. We previously reported the first PATHFINDER study that established feasibility of cancer screening with a blood-based multi-cancer early detection (MCED) tes...

A Scoping Review of Psychological Distress Outcomes in NICU Healthcare Providers

The Neonatal Intensive Care Unit (NICU) is a demanding work environment that provides medical care for acutely ill and premature infants while supporting parents experiencing significant stress and psychological distress. This scoping review is the first to examine quantitative r...

Factors Protecting Against Co-Occurring Pain, Psychological, and Somatic Symptom Trajectories in Adolescence

OBJECTIVE: To determine the relative impact of multilevel protective factors on co-occurring pain, psychological, and somatic symptom (co-PPSS) trajectories from late childhood through early adolescence. METHODS: We conducted secondary analyses of longitudinal Adolescent Brain Co...

What do master of nursing specialist students require during clinical practice? A qualitative study through the lens of workplace social capital networks

Advanced practice nurses (APNs) shoulder critical roles in the provision of advanced healthcare services. Master of Nursing Specialist (MNS) education, which aims to train specialized clinical talent, is the primary approach to cultivating APNs in China. MNS students are the focu...

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

Patients with high-risk endometrial carcinoma (HR-EC) experience substantial mortality despite multimodality therapy, molecular classification and contemporary care. We determined whether proteomic tumor programs capture lethal risk beyond established clinical and genomic classif...

Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways

Sporadic pancreatic neuroendocrine tumors (pNETs) with wild type MEN1 represent a major yet largely ignored subset whose biology and metastatic potential remain poorly understood. Because metastasis can occur despite low histologic grade and modest mutational burden, we hypothesi...

Development of items to assess noticeability and sun sensitivity among patients with non-segmental vitiligo

OBJECTIVES: Non-segmental vitiligo (NSV) is a chronic skin disease characterized by progressive, bilateral skin depigmentation that can impact health-related quality of life and psychosocial well-being. To assess emerging and new NSV treatments, patient-reported outcomes (PROs) t...

The Technology Dependence Index (TDI): Development and Validation in Neonatal and Pediatric Populations

The survival of infants and children with complex medical conditions continues to increase, underscoring the need to quantify technology dependence more effectively. Existing measures emphasize mortality risk and fail to capture the burden of ongoing technological support. To add...

Traumatic Catheter Removal‐ At‐Risk Populations, Outcomes and Prevention: A Retrospective Medical Record Review

AIMS: Traumatic catheter removal (TCR) occurs when a urinary catheter is removed with the balloon inflated, causing urethral injury. We aim to identify cases of TCR, determine at-risk populations and describe outcomes and interventions. DESIGN: Retrospective medical record review...

Postoperative factors associated with hazardous alcohol use after metabolic and bariatric surgery

Abstract Introduction There is an increased risk of hazardous alcohol use following metabolic and bariatric surgery (MBS). Identifying risk factors of hazardous alcohol use, particularly factors that may differentiate risk among those with regular postoperative alcohol consumptio...

Autonomic Nerve Fiber Compositions of Zygomaticotemporal and Lacrimal Nerves: A Cadaveric Immunohistochemical Analysis

Key Points Zygomaticotemporal (ZTN) and lacrimal nerves (LN) both carried sympathetics and parasympathetics ZTNs had more parasympathetics than LNs, but markers varied significantly within and between nerves LN parasympathetics to the lacrimal gland may mitigate dry eye after vid...

Exploring the Relationship Between Body Mass Index and Prostate Cancer Incidence: A Comprehensive Systematic Literature Review

Prostate cancer is the second leading cause of male cancer-related mortality in the United States, with an estimated 299,010 new cases and 35,250 deaths expected in 2024. This systematic literature review aims to explore the relationship between body mass index (BMI) and prostate...

Is Postinflammatory Hyperpigmentation Truly “Post” in People With Darker Skin Tones?

This Viewpoint reviews how inflammation can coexist with hyperpigmentation, explains why inflammatory activity may be underrecognized in people with darker skin tones, and proposes an approach in which hyperpigmentation prompts continued assessment for persistent inflammation.

How Equity and Quality Are Considered by Cancer Centers Offering Practice-Integrated Telehealth Visits: A Qualitative Study

INTRODUCTION: The COVID-19 pandemic forever changed health care delivery and led to a rapid uptake in telehealth visits. However, the quality and equity of these visits compared to in-person visits are unknown. This analysis interviewed oncology practitioners to understand how US...