Henan University Huaihe Hospital and Huaihe Clinical Institute

Role of PANoptosis in cancer: molecular mechanisms and therapeutic insights

Abnormal cell death plays a crucial role in cancer development. Inducing tumor cell death is an important strategy for cancer treatment. Against this backdrop, with the in-depth study of the regulatory mechanisms of cell death, the discovery of interactions existing among pyropto...

An FXR-dependent cellular program for Kupffer cell pool restoration fuels liver regeneration

Abstract Liver transplantation and partial hepatectomy represent the most effective therapeutic strategies for end-stage liver diseases. However, persistent donor organ shortages have intensified clinical interest in interventions that enhance liver regeneration. The farnesoid X...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...

Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants

2′,5’ oligoadenylate (2-5A) activates RNase L to degrade intracellular RNA and inhibit viral proliferation. The resulting nucleotide fragments bind RIG-I-like receptors to initiate type I interferon (IFN-I) signaling, enhancing maturation of antigen processing cells to trigger ad...