Henan Provincial Eye Hospital

Stage-specific nanotherapeutics for glaucoma target elevated IOP, impaired aqueous-humor outflow, RGC degeneration, and fibrotic inflammation during postoperative wound healing

Glaucoma is a chronic neurodegenerative disease in which elevated intraocular pressure (IOP), impaired aqueous-humor outflow, retinal ganglion cell (RGC) degeneration, and postoperative fibrosis may coexist or predominate at different stages. Conventional therapies are effective...

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

ABSTRACT Idiopathic pediatric uveitis (IPU) is a leading cause of irreversible vision loss in children; however, the genetic and molecular mechanisms underlying this condition remain unclear. Herein, trio‐based whole‐exome sequencing was performed in 28 affected families and targ...

Synchronous ReactiveOxygen Species Scavenging andImmunomodulation for Autoimmune Uveitis Therapy by a MannosylatedBiomimetic Nanocloak

Abstract Autoimmune uveitis is a recurrent, vision-threatening inflammatory disease that demands precise and ongoing treatment. However, current therapies have limitations in ocular targeting, in controlling reactive oxygen species (ROS), and in regulating key inflammatory pathwa...