Henan Provincial Chest Hospital

Targeting endothelial CYP3A5 in lung adenocarcinoma remodels the immunosuppressive microenvironment via VEGF inhibition: Mechanistic insights from Diosmetin

The tumor endothelium not only promotes angiogenesis but also actively fosters an immunosuppressive microenvironment in lung adenocarcinoma (LUAD). Cytochrome P450 enzymes, particularly CYP3A5, have emerged as potential regulators of endothelial function, yet their role in shapin...