Henan Cancer Hospital

Construction and validation of an intraoperative hypothermia prediction model in patients with breast cancer

Intraoperative hypothermia is a common issue in breast cancer patients with deep inferior epigastric perforator flap (DIEP), leading to complications. To construct an early warning model to investigate the risk factors of intraoperative hypothermia in patients undergoing breast r...

Oncolytic Virus-like Nanoparticle Targets the Golgi Apparatus via Sphingomyelin

Abstract The Golgi apparatus (GA) has emerged as a promising target for cancer therapy. Commonly, therapeutics are guided to the GA by recognizing specific receptors on the GA membrane. However, the low and heterogeneous expression of these receptors often results in suboptimal t...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

Rewiring lysosomal redox homeostasis for ferroptosis-amplified sonodynamic cancer therapy

Sonodynamic therapy (SDT) is a promising ROS-mediated antitumor strategy, yet its therapeutic efficacy is frequently restricted by intracellular antioxidant defenses and insufficient ferroptotic amplification. Herein, we developed a multi-stimuli-responsive metal-organic framewor...

Primary-tumor pathological response and postoperative residual nodal burden for risk stratification after neoadjuvant immunochemotherapy in gastric cancer

Primary-tumor regression and residual nodal disease may provide complementary prognostic information after neoadjuvant immunochemotherapy for locally advanced gastric cancer. This study evaluated whether integrating primary-tumor pathological response with the absolute residual p...

Bioinspired Surface Enabled by Anisotropic Pyramid Structure Arrays for Directional Liquid Self‐Transport

ABSTRACT Inspired by the phenomenon of directional liquid transport in natural organisms, various bionic surfaces with customized topological structures have been designed and fabricated, contributing to advances in such fields as microfluidics, microreactors, energy harvesting,...

Global distribution of lung cancer staging at diagnosis: a systematic review

Lung cancer remains the leading cause of cancer-related mortality worldwide, with stage at diagnosis significantly influencing survival outcomes. This systematic review evaluates global variations in lung cancer stage distribution at diagnosis and examines the associations of soc...

Determinants of a positive resection margin (R1 status) in esophageal squamous cell carcinoma: a retrospective analysis of 148,121 cases from China

To investigate risk factors for positive proximal and distal resection margins after surgery for esophageal squamous cell carcinoma (ESCC). Total initially enrolled esophageal squamous cell carcinoma patients were 148,121 cases. After strict case screening and quality control, a...

Secondary prevention of cancer therapy-induced thrombocytopenia with hetrombopag in breast cancer: a multicenter, randomized, exploratory phase II trial

Abstract Background: Cancer therapy-induced thrombocytopenia (CTIT) is a common complication of anti-tumor therapy, leading to treatment delays or interruptions, increased bleeding risk and compromised outcomes. In the present study, we aimed to evaluate the efficacy and safety o...

ATF7 drives diabetic wound healing via NOTCH1 repression and N1ICD-dependent macrophage polarization control

Chronic, non-healing wounds are a severe diabetic complication. The underlying mechanisms are not fully understood, and the role of ATF7 in this context has not been well characterized. In our study, we utilized db/db diabetic mice and AAV-mediated keratinocyte-specific Atf7 over...

XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is an aggressive malignancy that responds poorly to immune checkpoint inhibitor (ICI) therapy, due to its immunosuppressive tumor microenvironment. Here, we analyse preclinical mouse tumor models and patient-derived SCLC samples and identify...

P1.083. Sequential Versus Concurrent Neoadjuvant Immunochemotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized, Controlled, Open-Label, Phase II Trial

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemotherapy combined with PD-1 inhibitors has application potential for locally advanced esophageal squamous cell carcinoma (ESCC), but there is no prospective evidence for the optimal t...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Lysosome‐Targeted Self‐Adjuvanting Ammonia Nanogenerator Potentiates Hepatocellular Carcinoma Immunotherapy via Ammonia Death

ABSTRACT Ammonia death is a recently identified form of regulated cell death with unique molecular mechanisms and prominent anticancer activity. Nevertheless, its efficacy is severely restricted by the absence of tumor‐targeted ammonia delivery vehicles and poorly defined immunog...

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Abstract Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, the precise m...