Helmholtz Institute for Pharmaceutical Research Saarland

Tracheal tuft cell-released leukotrienes promote antibacterial immune responses

SUMMARY Tuft cells act as crucial sentinels in the airways that detect bacterial metabolites. In response, tuft cells release signaling molecules that trigger immune responses essential for clearing the infection. The molecular mechanisms driving immune cell activation following...

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

ABSTRACT Myxoglucamides, natural products recently isolated from Cystobacterineae sp., are featured by an unprecedented vinyl‐substituted α‐keto‐γ‐amino acid that is linked to a glycosylated 14‐methyl‐pentadecanoic acid. Thus, they unite elements from three biomolecular classes i...