Helmholtz Centre for Infection Research

The zlog value: a decade of standardizing laboratory results

Abstract Background The zlog transformation was developed in 2016 as a method-independent and unit-independent standardization of laboratory results for the German Electronic Health Record (ePA). Based on the assumption of a log-normal distribution and the known lower and upper r...

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

Abstract Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs. Phages represent a promising therapeutic alternative to antibiotics owing to their host specificit...

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

ABSTRACT Myxoglucamides, natural products recently isolated from Cystobacterineae sp., are featured by an unprecedented vinyl‐substituted α‐keto‐γ‐amino acid that is linked to a glycosylated 14‐methyl‐pentadecanoic acid. Thus, they unite elements from three biomolecular classes i...