Heidelberg University

Rapid and Efficient Affinity Isolation of Engineered Extracellular Vesicles Encapsulating Functional Proteins via Internal Twin‐Strep Tetraspanin Tagging

ABSTRACT Extracellular vesicles (EVs) are mediators of intercellular communication and promising protein‐delivery vehicles, but isolation of sufficiently pure, intact, engineered EVs remains challenging due to abundant cellular and serum‐derived contaminants. Here, structure‐guid...

AI Dermatology's Unfulfilled Promise: Why Early Melanoma Detection Remains Unverified

A growing number of artificial intelligence (AI) systems for melanoma diagnosis now match dermatologist-level performance. Early detection is a driving factor, yet it is rarely validated beyond aggregate diagnostic accuracy. More targeted studies are necessary so these claims bec...

A review of selected Swedish contributions to instrumentation at neutron scattering facilities

Abstract The European Spallation Source in Lund, Sweden, is the next generation neutron research facility that will provide unprecedented capabilities for particle physics as well as materials and life science research through its high brightness, long-pulse neutron source and ad...

The Geography of Partnerships in Latin American Climate NGOs and the Limits of South–South Cooperation

ABSTRACT Post‐aid scholarship suggests cooperation among non‐state actors in middle‐income regions has become less Northern‐anchored and more geographically dispersed. At the same time, optimistic readings of polycentric climate governance imply that decentralisation may loosen N...

Altered Membrane Protein Abundance in the Cerebral Cortex of the JNPL3 Mouse Model of Tauopathy

Abstract Developing effective therapeutic approaches for tau-associated neurodegenerative diseases, including frontotemporal dementia and Alzheimer’s disease, remains extremely challenging due to their complex pathogeneses. Membrane proteins constitute a large proportion of curre...

Assessing glymphatic role in the association between choroid plexus enlargement and white matter lesions load: The uncertain path through diffusion tensor imaging along the perivascular space (DTI-ALPS)

Background The choroid plexus (CP) is involved in cerebrospinal fluid production, immune surveillance, and brain fluid homeostasis. CP enlargement has been linked to neuroinflammation, glymphatic dysfunction, and white matter lesion (WML) burden, but the mechanisms underlying the...

Long-term open-path dual-comb spectroscopy for urban CO 2 monitoring

Abstract. Accurate quantification of urban greenhouse gas (GHG) emissions can benefit from path-averaged, high-precision, high-temporal-resolution measurements that complement point sensors and passive remote sensing. Among open-path techniques, dual-comb spectroscopy (DCS) stand...

Solution-processed flexible neutron converter foils

Abstract The cost increase of helium-3 has sparked the development of alternative detection technologies, specifically the use of boron carbide converters is one of the pillars of next-generation neutron detectors. While producing high-quality films, sputter-coating is limited in...

Assessing climate change-related health hazards: An interactive tool for regional risk analysis in Germany

An interactive online health risk assessment has been created to visualize the health risks associated with climate change at the district level (NUTS3) across Germany. The tool provides a comprehensive assessment by depicting both the current risk patterns and projected conditio...

The parameter estimation tables (PEtab) format version 2

Abstract Parameter estimation is a central task in data-driven computational modeling, and a clear, unambiguous, and commonly understood specification of parameter estimation problems is essential for reproducibility and interoperability. PEtab provides a standardized framework f...

Reduction of postoperative care unit observation time following carotid endarterectomy: a targeted approach

To evaluate the safety and feasibility of reducing the postoperative care unit (POCU) observation period from four hours to two hours following carotid endarterectomy (CEA) for asymptomatic, high grade carotid stenosis. Monocentric, retrospective-prospective observational cohort...

EFECT enables reliable and reproducible stochastic simulations across disciplines

Stochastic simulations underpin computational research in fields from systems biology and epidemiology to finance and physics-informed machine learning, yet their reproducibility is hard to quantify because each run yields different outcomes. Existing practices to improve computa...