Hebron University

Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments

BACKGROUND: Early recognition of sepsis in emergency departments (EDs) improves outcomes and reduces healthcare resource use. However, current clinical practice (CCP), largely based on the National Early Warning Score 2 (NEWS2) and clinical judgement, has limited diagnostic sensi...

Pelvic heterotopic ossification causing bladder compression: a rare post-traumatic case report

Introduction: Heterotopic ossification (HO) is the pathological formation of bone within soft tissues, most commonly following trauma or surgery. Pelvic HO that causes direct mechanical compression of the urinary bladder is exceptionally rare. We present a case that remained asym...

Repetitive Transcranial Magnetic Stimulation for Cocaine Use Disorder: An Observational Study

Background: Cocaine use disorder (CUD) presents high relapse rates and limited treatment options. Repetitive transcranial magnetic stimulation (rTMS) has shown promise, but evidence in clinical practice is scarce. Methods: We conducted a naturalistic retrospective study using med...

SEC22B modulates ClC-5/TMEM9 trafficking and serves as a urinary marker for Dent’s Disease

The Cl − /H + antiporter ClC-5 is a key regulator of renal proximal tubule function, primarily by controlling endosomal acidification. Loss-of-function mutations in ClC-5 cause Dent’s Disease type 1 (DD1), a rare renal tubulopathy that progresses to kidney failure with significan...

High-throughput engineering of bispecific antibodies to enhance macrophage-mediated cytotoxicity of B-cell lymphoma

Abstract Macrophages are critical effectors of antibody therapies for lymphoma, but the best targets to engage their function remain unknown. Here, we develop a ‘tactical surfaceome profiling’ strategy to define a comprehensive repertoire of surface antigens on B-cell lymphoma th...

Oral cavity cancer knowledge and clinical practices among medical students and interns in the West Bank: a cross-sectional study

Oral cavity cancer (OCC) remains a major global public health challenge, with disproportionately high morbidity and mortality in developing regions. In the West Bank, OCC incidence and mortality are among the highest in the Middle East and North Africa. As primary care physicians...

Prevalence of poor sleep quality among Palestinian breast cancer patients and the associated factors: a cross-sectional study

Sleep disturbances are common among patients with breast cancer and may substantially impair quality of life, emotional well-being, and treatment experiences. However, evidence from Palestine and similar low- and middle-income settings remains scarce. This study aimed to assess t...