Hebei University of Science and Technology

A Novel polymer planar biomimetic membrane with self-differentiating intestinal-like structural for drug permeability prediction

Accurately and efficiently assessing the drug permeability are emerging as the big challenge early in new drug discovery and development, thus various models have been developed. Here, a polymer planar biomimetic membrane permeation assay (PPBMPA) model was constructed in a trans...

Disclosing Structural Determinants Governing Stereopreferences of Ketoreductases toward Reduction of Halogenated Aryl Ketones

Abstract Ketoreductases (KREDs) are widely used for asymmetric ketone reduction, yet predictable control of stereoselectivity remains challenging due to the limited understanding of structure–selectivity relationships. Here, we integrate site-directed mutagenesis and molecular dy...

Unveiling the determinants and formation mechanisms of the intention-behavior gap among private enterprises participating in new infrastructure construction

Purpose A disconnect between the intention to participate and the actual engagement among private enterprises is impeding the effective promotion of new infrastructure construction (NIC). To address this critical barrier, this study aims to identify the determinants of this inten...

Ferroresonance in power systems: A structured technical review and mitigation strategies

Ferroresonance is a complex and potentially destructive phenomenon that poses significant risks to the reliability and stability of power distribution systems. Although incidents have been documented for more than a century, the underlying mechanisms and effective countermeasures...

Effect of mesh-belt motor frequency on heat- transfer boundary conditions and quenching distortion of bearing rings

Quenching distortion of bearing rings seriously affects their dimensional accuracy and service performance in industrial production. To address this issue, this study proposes a distortion control method for bearing rings during quenching in widely used mesh-belt furnaces, focusi...

Bifacial InterfaceEngineering of Perovskite Memristorsfor High-Performance Optoelectronic Synapses and Neuromorphic VisionSystems

Abstract Conventional complementary metal-oxide-semiconductor (CMOS)-based intelligent visual systems suffer from inherent bottlenecks of high energy consumption and latency, while perovskite memristors are constrained by critical issues including defect-induced instability, unim...

Systematic ConditionsOptimization of Kilometer-ScaleAramid Fiber with High Tensile Strength via Microfluidic Spinning

Abstract Poly(p-phenylene benzimidazole-benzamide) (PBIA) fiber, with superior mechanical properties, has become a promising chemically synthesized high-performance aramid fiber. The crystallization and orientation behaviors of PBIA fiber critically determine its comprehensive pr...

Bioinspired Molecular Magnetic Field-Responsive Catalyst for On-Demand Switching of 2e− and 4e− Oxygen Reduction

Abstract Achieving precise and on-demand steering of the oxygen reduction reaction (ORR) pathway between the efficient 4e − route to H 2 O and the valuable 2e − route to H 2 O 2 remains a pivotal challenge in electrocatalysis. Herein, we address this challenge by designing a bioi...

Strain Effectson the Mechanical Properties and GasAdsorption and Diffusion Characteristics of Anthracite

Abstract The coal matrix is subjected to complex strain conditions during exploration. Pore structural evolution, gas adsorption, and diffusion characteristics of high-rank coal matrix under uniaxial compressive and tensile strain conditions are investigated through molecular sim...