Hebei University of Chinese Medicine

Development and temporal validation of a predictive model for difficult laparoscopic cholecystectomy

Abstract Background Difficult laparoscopic cholecystectomy (LC) is associated with an increased risk of intraoperative complications. This study aimed to develop and validate a preoperative nomogram for predicting difficult LC. Materials and methods A retrospective study included...

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

ABSTRACT Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significant...

Shenling Qige Granules inhibit esophageal squamous cell carcinoma progression in TE-1 xenograft and cell-based models by modulating the DCN–TGF-β/Smad signaling axis

Shenling Qige Granules (SLQG), derived from the Qing Dynasty formula Qige San recorded in Yi Xue Xin Wu , has been used in clinical practice in China as an adjuvant traditional Chinese medicine preparation for esophageal squamous cell carcinoma (ESCC), but its molecular basis rem...

Bioinspired Surface Enabled by Anisotropic Pyramid Structure Arrays for Directional Liquid Self‐Transport

ABSTRACT Inspired by the phenomenon of directional liquid transport in natural organisms, various bionic surfaces with customized topological structures have been designed and fabricated, contributing to advances in such fields as microfluidics, microreactors, energy harvesting,...

Identification and expression validation of key genes of Xiaozhengtongluo formula in the treatment of diabetic nephropathy by Mendelian randomization

Xiaozhengtongluo formula (XZTL) has a positive effect on the treatment of diabetic nephropathy (DN), but its mechanism is not fully understood. Therefore, it is important to explore the key genes of XZTL in the treatment of DN. Differentially expressed genes (DEGs) between DN and...

Perfluorodecanoic acid (PFDA) exposure, through stabilizing HIF-1α to induce VEGF/VEGFR2 autocrine signaling, promotes colorectal cancer cell proliferation

Perfluorodecanoic acid (PFDA) is a persistent organic pollutant widely present in the environment and resistant todegradation. In recent years, due to its extensive use in industrial production and consumer products, PFDA continuously accumulates in organisms and has become a glo...

Active ingredients of Astragalus–ginseng against COPD-associated sarcopenia: network pharmacology and molecular dynamics simulations

Background Chronic obstructive pulmonary disease (COPD)-associated sarcopenia is a critical comorbidity associated with high morbidity and mortality, driven by chronic systemic inflammation, oxidative stress, and proteometabolic dysregulation. The Astragalus membranaceus-Ginseng...

AP-1-IL-1β signaling pathway on impulsive-like behavior and memory deficits in aged mice under tibial plateau fracture conditions

Tibial fracture surgery has attracted significant interest as a notable trigger for PND. Under external stimuli such as anesthesia and surgery, the transcription factor AP-1 regulates the abnormal expression of glutamatergic neurons via interleukin-1β (IL-1β), a mechanism closely...

HMGA1 accelerates vascular smooth muscle cell osteogenic phenotype transdifferentiation by elevating pro-inflammatory cytokine IL-1β transcription in chronic kidney disease

Abstract Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is recognized as a core pathological process underlying vascular calcification (VC). The inflammatory response contributes to the development of phenotypic switch, yet there is a lack of therapeutic strat...

Single-Cell RNA Sequencing Reveals Disrupted Stromal-Epithelial Crosstalk Impairs Gut Barrier in Depression.

BACKGROUND: Depressive disorder is commonly associated with gastrointestinal dysfunction, but the specific cellular and molecular alterations within the colonic mucosa remain poorly understood. The role of stromal-epithelial crosstalk in the colonic niche under depressive conditi...