Hebei University of Chinese Medicine

AP-1-IL-1β signaling pathway on impulsive-like behavior and memory deficits in aged mice under tibial plateau fracture conditions

Tibial fracture surgery has attracted significant interest as a notable trigger for PND. Under external stimuli such as anesthesia and surgery, the transcription factor AP-1 regulates the abnormal expression of glutamatergic neurons via interleukin-1β (IL-1β), a mechanism closely...

HMGA1 accelerates vascular smooth muscle cell osteogenic phenotype transdifferentiation by elevating pro-inflammatory cytokine IL-1β transcription in chronic kidney disease

Abstract Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is recognized as a core pathological process underlying vascular calcification (VC). The inflammatory response contributes to the development of phenotypic switch, yet there is a lack of therapeutic strat...

Single-Cell RNA Sequencing Reveals Disrupted Stromal-Epithelial Crosstalk Impairs Gut Barrier in Depression.

BACKGROUND: Depressive disorder is commonly associated with gastrointestinal dysfunction, but the specific cellular and molecular alterations within the colonic mucosa remain poorly understood. The role of stromal-epithelial crosstalk in the colonic niche under depressive conditi...